SARS-CoV-2 tropism across the upper aerodigestive tract
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/20587384211056840
Abstract: Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is related to epithelial expression of angiotensin-converting enzyme II (ACE2) that plays a pivotal role in regulating viral entry. ACE2, a type 1 membrane-bound enzyme located… read more here.
Keywords: expression; sars cov; aerodigestive tract; cov tropism ... See more keywords
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14030535
Abstract: Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection.… read more here.
Keywords: k18 hace2; hace2; neurodissemination; cov tropism ... See more keywords