Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity
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DOI: 10.1001/jamanetworkopen.2023.10650
Abstract: Key Points Question How does the effectiveness of COVID-19 vaccines against laboratory-confirmed Omicron infection and symptomatic disease change at different times from last dose administration and number of doses, and how does this compare with… read more here.
Keywords: waning sars; vaccine induced; evaluation waning; vaccine ... See more keywords
Immunogenicity and Safety of a Third SARS-CoV-2 Vaccine Dose in Patients With Multiple Sclerosis and Weak Immune Response After COVID-19 Vaccination
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DOI: 10.1001/jamaneurol.2021.5109
Abstract: This cohort study investigates the immunogenicity and safety of a third SARS-CoV-2 vaccine dose in patients with multiple sclerosis who had a weak immune response to COVID-19 vaccination. read more here.
Keywords: immunogenicity safety; third sars; vaccine dose; safety third ... See more keywords
B Cell Depletion and SARS‐CoV‐2 Vaccine Responses in Neuroimmunologic Patients
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DOI: 10.1002/ana.26309
Abstract: The study was undertaken to assess the impact of B cell depletion on humoral and cellular immune responses to severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccination in patients with various neuroimmunologic disorders on anti‐CD20 therapy.… read more here.
Keywords: cell depletion; depletion sars; vaccine responses; sars cov ... See more keywords
Regeneration of Capto Core 700 resin through high throughput and laboratory scale studies and impact on production of a SARS‐CoV‐2 vaccine candidate
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DOI: 10.1002/biot.202200191
Abstract: During the development of a SARS‐CoV‐2 vaccine candidate, at the height of the COVID‐19 pandemic, raw materials shortages, including chromatography resins, necessitated the determination of a cleaning in place (CIP) strategy for a multimodal core‐shell… read more here.
Keywords: core; vaccine candidate; resin; capto core ... See more keywords
A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice
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DOI: 10.1002/eji.202149167
Abstract: Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene for the SARS‐CoV‐2 S1 subunit antigen (Ad5.SARS‐CoV‐2‐S1) for COVID‐19 immunization… read more here.
Keywords: responses mice; immunization; cov vaccine; immune responses ... See more keywords
A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS-CoV-2 vaccine.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27334
Abstract: Neutralizing antibodies in volunteers who received two doses of an inactivated SARS-CoV-2 vaccine deceased over several months. A three-dose procedure study suggested that the boost conferred by a third dose rescued the waning of neutralizing… read more here.
Keywords: cov vaccine; sars cov; doses inactivated; booster dose ... See more keywords
Comparison of immune responses induced by two or three doses of an alum‐adjuvanted inactivated SARS‐CoV‐2 vaccine in mice
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DOI: 10.1002/jmv.27637
Abstract: Waning antibodies and rapidly emerging variants are challenges for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccine development. Adjusting existing immunization schedules and further boosting strategies are under consideration. Here, the immune responses induced by… read more here.
Keywords: inactivated sars; adjuvanted inactivated; alum adjuvanted; schedule ... See more keywords
Receptor‐binding domain‐based SARS‐CoV‐2 vaccine adjuvanted with cyclic di‐adenosine monophosphate enhances humoral and cellular immunity in mice
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DOI: 10.1002/jmv.28584
Abstract: Novel adjuvants are highly desired to improve immune responses of SARS‐CoV‐2 vaccines. This work reports the potential of the stimulator of interferon genes (STING) agonist adjuvant, the cyclic di‐adenosine monophosphate (c‐di‐AMP), in a SARS‐CoV‐2 vaccine… read more here.
Keywords: rbd; amp; mice; sars cov ... See more keywords
Stable and durable antibody responses in SARS‐recovered donors vaccinated with inactivated SARS‐CoV‐2 vaccine
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DOI: 10.1002/jmv.28662
Abstract: Whether the immune imprinting caused by severe acute respiratory syndrome coronavirus (SARS‐CoV) affects the efficiency of SARS‐CoV‐2 vaccination has attracted global concern. Little is known about the dynamic changes of antibody response in SARS convalescents… read more here.
Keywords: sars recovered; inactivated sars; recovered donors; sars cov ... See more keywords
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic
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DOI: 10.1007/s11684-021-0913-y
Abstract: The record speed at which Chinese scientists identified severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and shared its genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19) diagnostics, drugs, and… read more here.
Keywords: cov vaccine; sars cov; immunization strategies; research ... See more keywords
Inactivated SARS-CoV-2 vaccine for people with HIV
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DOI: 10.1016/j.eclinm.2022.101327
Abstract: eClinicalMedicine 2022;45: 101327 Published online xxx https://doi.org/10.1016/j. eclinm.2022.101327 HIV patients are at increased risk of COVID-19 morbidity and mortality. Moreover, increased SARS-CoV-2 mutation development has been reported in (African) HIV-1 infected patients. Previous reports documented… read more here.
Keywords: hiv infected; cov vaccine; safety immunogenicity; sars cov ... See more keywords