Combinatorially Screened Peptide as Targeted Covalent Binder: Alteration of Bait-Conjugated Peptide to Reactive Modifier.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00301
Abstract: A peptide-type covalent binder for a target protein was obtained by combinatorial screening of fluoroprobe-conjugated peptide libraries on bacteriophage T7. The solvatochromic fluoroprobe works as a bait during the affinity selection process of phage display.… read more here.
Keywords: targeted covalent; conjugated peptide; bait; binder ... See more keywords
Identification of a covalent binder to the oncoprotein gankyrin using a NIR-Based OBOC screening method
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra10976b
Abstract: Despite huge advancements in the process of synthesizing small molecules as part of one-bead-one-compound (OBOC) libraries, progress lags in the ability to rank potential hits from a primary library screen. read more here.
Keywords: covalent binder; gankyrin using; identification covalent; binder oncoprotein ... See more keywords