Ubiquitin C‐Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine‐Based Inhibitor
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DOI: 10.1002/cbic.201900434
Abstract: The deubiquitinase (DUB) ubiquitin C‐terminal hydrolase L1 (UCHL1) is expressed primarily in the central nervous system under normal physiological conditions. However, UCHL1 is overexpressed in various aggressive forms of cancer with strong evidence supporting UCHL1… read more here.
Keywords: terminal hydrolase; ubiquitin terminal; cyanopyrrolidine based; biochemical cellular ... See more keywords