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Published in 2023 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.3c00232
Abstract: Covalent drug design is an important component in drug discovery. Traditional drugs interact with their target in a reversible equilibrium, while irreversible covalent drugs increase the drug-target interaction duration by forming a covalent bond with…
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Keywords:
covalent drug;
drug design;
site identification;
identification ligand ... See more keywords
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Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a136
Abstract: There is currently a resurgence of interest in developing covalent drugs due to the high potency, good selectivity, and prolonged effects which may results in less-frequent drug dosing and wider therapeutic windows for patients. BridGene…
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Keywords:
covalent drug;
drug;
small molecule;
imtactm ... See more keywords