Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
Sign Up to like & getrecommendations! Published in 2022 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0396
Abstract: Abstract Ubiquitination is a key regulatory mechanism vital for maintenance of cellular homeostasis. Protein degradation is induced by E3 ligases via attachment of ubiquitin chains to substrates. Pharmacological exploitation of this phenomenon via targeted protein… read more here.
Keywords: fragment based; covalent fragment; identification; proteasome ... See more keywords
Covalent fragment inhibits intramembrane proteolysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.958399
Abstract: Alzheimer’s disease (AD) is a serious public health crisis with only one current modifying treatment. The reduction of amyloid load by targeting γ-secretase (GS) has been a leading approach in AD drug discovery and development.… read more here.
Keywords: fragment inhibits; covalent fragment; intramembrane proteolysis; inhibits intramembrane ... See more keywords