Covalent modification of flaxseed protein isolate by phenolic compounds and the structure and functional properties of the adducts.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.04.123
Abstract: Covalent modification of flaxseed protein isolate by phenolic compounds including flaxseed polyphenols, ferulic acid, and hydroxytyrosol was studied under alkaline condition and in the presence of oxygen. The structure and function of the adducts was… read more here.
Keywords: isolate phenolic; phenolic compounds; covalent modification; protein isolate ... See more keywords
Histone Deacetylase 1 Inhibition by Peptides Containing a DNA Damage-Induced, Nonenzymatic, Histone Covalent Modification.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00007
Abstract: Treatment of HeLa cells with the DNA damaging agent, bleomycin (BLM), results in the formation of a nonenzymatic 5-methylene-2-pyrrolone histone covalent modification on lysine residues (KMP). KMP is much more electrophilic than other N-acyllysine covalent… read more here.
Keywords: modification; histone; kmp; peptides containing ... See more keywords
Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00140
Abstract: Inhibition of monoglyceride lipase (MGL), also known as monoacylglycerol lipase (MAGL), has emerged as a promising approach for treating neurological diseases. To gain useful insights in the design of agents with balanced potency and reactivity,… read more here.
Keywords: monoglyceride lipase; covalent modification; mgl; lipase ... See more keywords
Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-29338-w
Abstract: Engineered signaling networks can impart cells with new functionalities useful for directing differentiation and actuating cellular therapies. For such applications, the engineered networks must be tunable, precisely regulate target gene expression, and be robust to… read more here.
Keywords: covalent modification; expression; mammalian cells; cell ... See more keywords
Covalent Modification by Glyoxals Converts Cytochrome c Into its Apoptotically Competent State
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41282-2
Abstract: The effects of glycation by glyoxal (Gly) and methylglyoxal (MGly) on the early and late conformational alterations in Cytochrome c (Cyt c) were studied. Spectroscopic measurements revealed that Cyt c undergo certain conformational alterations and… read more here.
Keywords: converts cytochrome; cytochrome apoptotically; modification glyoxals; covalent modification ... See more keywords
Liquid-phase photo-induced covalent modification (PICM) of single-layer graphene by short-chain fatty acids.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr06698j
Abstract: We report an efficient photo-induced covalent modification (PICM) of graphene by short-chain fatty acids (SCFAs) with an alkyl chain at the liquid-solid interface for spatially resolved chemical functionalization of graphene. Light irradiation on monolayer graphene… read more here.
Keywords: graphene; photo induced; picm; covalent modification ... See more keywords
Abstract 3424: Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3424
Abstract: Molecular glue degraders have emerged as a powerful class of small-molecule therapeutics, as demonstrated by the clinical successes of thalidomide analogs in the treatment of hematological malignancies. These small molecules act by recruiting ubiquitin ligases… read more here.
Keywords: dcaf16; glue degraders; covalent modification; molecular glue ... See more keywords
Introduction to serial reviews: Current progress in covalent modification of biomolecules by compounds in food or oxidatively generated compounds - its relevance to biological functions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.17-200
Abstract: J. Clin. Biochem. Nutr. | May 2018 | vol. 62 | no. 3 | 213–220 doi: 10.3164/jcbn.18 26 ©2018 JCBN JCBN ournal of Clinical Biochemistry and Nutrition 0912-0009 1880 5 86 the Society for Free… read more here.
Keywords: biochemistry; current progress; progress covalent; modification biomolecules ... See more keywords