NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
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DOI: 10.1038/s41467-021-20963-5
Abstract: The Neisseria meningitidis protein FrpC contains a self-processing module (SPM) undergoing autoproteolysis via an aspartic anhydride. Herein, we establish NeissLock, using a binding protein genetically fused to SPM. Upon calcium triggering of SPM, the anhydride… read more here.
Keywords: protein; covalent; neisslock provides; covalent targeting ... See more keywords