Bicyclobutanes: from curiosities to versatile reagents and covalent warheads
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc03948f
Abstract: The unique chemistry of small, strained carbocyclic systems has long captivated organic chemists from a theoretical and fundamental standpoint. A resurgence of interest in strained carbocyclic species has been prompted by their potential as bioisosteres,… read more here.
Keywords: bicyclobutanes curiosities; versatile reagents; chemistry; covalent warheads ... See more keywords
Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27227728
Abstract: Cysteine is one of the least abundant amino acids in proteins of many organisms, which plays a crucial role in catalysis, signal transduction, and redox regulation of gene expression. The thiol group of cysteine possesses… read more here.
Keywords: development; cysteine; covalent warheads; cysteine residue ... See more keywords