Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis
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DOI: 10.1007/s43440-020-00169-0
Abstract: Background A large body of research has focused on fluoroquinolones. It was shown that this class of synthetic antibiotics could possess antiviral activity as a broad range of anti-infective activities. Based on these findings, we… read more here.
Keywords: covid main; protease; ciprofloxacin moxifloxacin; main protease ... See more keywords
Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2)
Sign Up to like & getrecommendations! Published in 2021 at "Biocatalysis and Agricultural Biotechnology"
DOI: 10.1016/j.bcab.2021.101924
Abstract: The outbreak of COVID-19 created unprecedented strain in the healthcare system. Various research revealed that COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2) are responsible for viral replication and entry into the human… read more here.
Keywords: covid main; mpro human; molecular dynamics; main protease ... See more keywords
Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main protease
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e05641
Abstract: Drug repurposing is the most rapid and economic way nowadays to rapidly provide effective drugs for our pandemic coronavirus disease 2019 (COVID-19). It was a great debate about ARBs whether to be stopped or continued… read more here.
Keywords: covid main; main protease; molecular docking; protease molecular ... See more keywords
Inhibitory activity of hydroxychloroquine on COVID-19 main protease: An insight from MD-simulation studies
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DOI: 10.1016/j.molstruc.2020.128595
Abstract: Abstract The present work is an investigation to test hydroxychloroquine as an inhibitor for the COVID-19 main protease. Molecular docking studies revealed a high docking score and interaction energies and decent level of docking within… read more here.
Keywords: covid main; hydroxychloroquine; protease; main protease ... See more keywords
Isolation and In Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana
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DOI: 10.1155/2021/5547013
Abstract: The emergence of the COVID-19 pandemic declared the huge need of humanity for new and effective antiviral drugs The reported antimicrobial activities of Artemisia sublessingiana encouraged us to investigate the ethanol extract of its aerial… read more here.
Keywords: covid main; artemisia sublessingiana; chemistry; covid ... See more keywords