Inflammasome regulation in driving COVID‐19 severity in humans and immune tolerance in bats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4covhr0221-093rr
Abstract: Coronaviruses (CoVs) are RNA viruses that cause human respiratory infections. Zoonotic transmission of the SARS‐CoV‐2 virus caused the recent COVID‐19 pandemic, which led to over 2 million deaths worldwide. Elevated inflammatory responses and cytotoxicity in… read more here.
Keywords: severity humans; covid severity; immune tolerance; severity ... See more keywords
Role of vitamin D in regulating COVID‐19 severity—An immunological perspective
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4covr1020-698r
Abstract: Vitamin D, a key nutrient/prohormone classically associated with skeletal health, is also an important immunomodulator, with pleotropic effects on innate and adaptive immune cells. Outcomes of several chronic, autoimmune, and infectious diseases are linked to… read more here.
Keywords: disease severity; covid severity; respiratory disease; severity ... See more keywords
Human seasonal coronavirus neutralization and COVID‐19 severity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27937
Abstract: The virus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the global coronavirus disease‐2019 (COVID‐19) pandemic, spread rapidly around the world causing high morbidity and mortality. However, there are four known, endemic seasonal coronaviruses… read more here.
Keywords: covid severity; coronavirus; neutralization; sars cov ... See more keywords
Cross‐sectional analysis reveals autoantibody signatures associated with COVID‐19 severity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28538
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID‐19 patients may develop a broad spectrum… read more here.
Keywords: infection; covid severity; autoantibody; autoantibody signatures ... See more keywords
Genetic characteristics involved in COVID‐19 severity. The CARGENCORS case‐control study and meta‐analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29404
Abstract: Pre‐existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID‐19 disease severity. However, the association of candidate single nucleotide variants (SNVs) related to mechanisms of COVID‐19 complications… read more here.
Keywords: covid severity; severity; severity cargencors; meta analysis ... See more keywords
Categorization of COVID-19 severity to determine mortality risk.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacoepidemiology and drug safety"
DOI: 10.1002/pds.5436
Abstract: PURPOSE Algorithms for classification of inpatient COVID-19 severity are necessary for confounding control in studies using real-world data. METHODS Using Healthverity chargemaster and claims data, we selected patients hospitalized with COVID-19 between April 2020 and… read more here.
Keywords: severity; mortality; covid severity; mortality risk ... See more keywords
Development and validation of prognostic scoring system for COVID-19 severity in South India
Sign Up to like & getrecommendations! Published in 2022 at "Irish Journal of Medical Science"
DOI: 10.1007/s11845-021-02876-w
Abstract: Background Development of a prediction model using baseline characteristics of COVID-19 patients at the time of diagnosis will aid us in early identification of the high-risk groups and devise pertinent strategies accordingly. Hence, we did… read more here.
Keywords: prognostic scoring; covid severity; model; scoring system ... See more keywords
Do inflammasome impact COVID-19 severity?
Sign Up to like & getrecommendations! Published in 2021 at "VirusDisease"
DOI: 10.1007/s13337-021-00705-3
Abstract: COVID-19 pandemic has proven to be a dramatic challenge, introducing huge clinical differences that demand extensive investigations. Severe and critical patients may present coagulopathies and microthrombi, which results in varied complications, or acute respiratory distress… read more here.
Keywords: impact covid; inflammasome impact; covid severity;
Associations between COVID-19 risk perceptions and smoking and quitting behavior among U.S. adults
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DOI: 10.1016/j.abrep.2021.100394
Abstract: Objectives The COVID-19 pandemic may impact cigarette smokers’ behaviors. Among smokers, perceptions about the risks of contracting COVID-19 and the severity of COVID-19 illness likely vary, and perceptions may be associated with individual smoking behavior.… read more here.
Keywords: risk perceptions; covid severity; smoking quitting; quit ... See more keywords
14 External Validation of the Quick COVID-19 Severity Index: A Prognostic Tool for Early Clinical Decompensation
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Emergency Medicine"
DOI: 10.1016/j.annemergmed.2021.07.015
Abstract: Study Objective: To externally validate a risk-stratification tool—the Quick COVID-19 Severity Index (qCSI)—developed by Haimovich et al. to predict 24-hour respiratory decompensation in admitted patients with COVID-19. Methods: This was a retrospective observational cohort study… read more here.
Keywords: quick covid; severity index; study; covid ... See more keywords
Large-Scale Multi-omic Analysis of COVID-19 Severity
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DOI: 10.1016/j.cels.2020.10.003
Abstract: We performed RNA-Seq and high-resolution mass spectrometry on 128 blood samples from COVID-19 positive and negative patients with diverse disease severities and outcomes. Quantified transcripts, proteins, metabolites, and lipids were associated with clinical outcomes in… read more here.
Keywords: large scale; analysis; covid; severity ... See more keywords