Association of gut microbiota with COVID‐19 susceptibility and severity: A two‐sample Mendelian randomization study
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DOI: 10.1002/jmv.28734
Abstract: Evidence supports the observational associations of gut microbiota with the risk of COVID‐19; however, it is unclear whether these associations reflect a causal relationship. This study investigated the association of gut microbiota with COVID‐19 susceptibility… read more here.
Keywords: covid susceptibility; severity; microbiota; gut microbiota ... See more keywords
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
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DOI: 10.1038/s41591-021-01281-1
Abstract: To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding.… read more here.
Keywords: susceptibility; covid susceptibility; oas1; susceptibility severity ... See more keywords
COVID-19 susceptibility and severity risks in a cross-sectional survey of over 500 000 US adults
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DOI: 10.1136/bmjopen-2021-049657
Abstract: Objectives The enormous toll of the COVID-19 pandemic has heightened the urgency of collecting and analysing population-scale datasets in real time to monitor and better understand the evolving pandemic. The objectives of this study were… read more here.
Keywords: cross sectional; covid susceptibility; susceptibility; self reported ... See more keywords
Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-02973-5
Abstract: Background The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evidence supporting the… read more here.
Keywords: covid susceptibility; causal; covid; severity ... See more keywords
Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis
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DOI: 10.1371/journal.pmed.1003553
Abstract: Background Epidemiological studies report associations of diverse cardiometabolic conditions including obesity with COVID-19 illness, but causality has not been established. We sought to evaluate the associations of 17 cardiometabolic traits with COVID-19 susceptibility and severity… read more here.
Keywords: risk; susceptibility; covid susceptibility; covid ... See more keywords
COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases
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DOI: 10.1371/journal.pone.0256988
Abstract: Epidemiological studies suggest that individuals with comorbid conditions including diabetes, chronic lung, inflammatory and vascular disease, are at higher risk of adverse COVID-19 outcomes. Genome-wide association studies have identified several loci associated with increased susceptibility… read more here.
Keywords: blood clots; risk; susceptibility; covid susceptibility ... See more keywords
ACE2 and COVID-19 Susceptibility and Severity
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DOI: 10.14336/ad.2021.0805
Abstract: Sick, male, and older populations are more vulnerable to COVID-19. However, it remains unclear whether a common mechanism exists across different demographic characteristics. SARS-CoV-2 infection is initiated by the specific binding of the viral spike… read more here.
Keywords: covid susceptibility; covid; ace2 covid; ace2 ... See more keywords
Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-21-0996
Abstract: Context A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression for viral susceptibility, nor… read more here.
Keywords: covid susceptibility; covid; susceptibility; androgen synthesis ... See more keywords
Causal associations between thyroid dysfunction and COVID-19 susceptibility and severity: A bidirectional Mendelian randomization study
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DOI: 10.3389/fendo.2022.961717
Abstract: Background Observational studies have reported an association between coronavirus disease 2019 (COVID-19) risk and thyroid dysfunction, but without a clear causal relationship. We attempted to evaluate the association between thyroid function and COVID-19 risk using… read more here.
Keywords: covid susceptibility; covid; thyroid dysfunction; severity ... See more keywords
Are inflammatory bowel diseases associated with an increased risk of COVID-19 susceptibility and severity? A two-sample Mendelian randomization study
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DOI: 10.3389/fgene.2023.1095050
Abstract: Background: Due to inconsistent findings in observational studies regarding the relationship between inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), and COVID-19, our objective is to explore a potential causative correlation… read more here.
Keywords: covid susceptibility; susceptibility; study; susceptibility severity ... See more keywords
Relationship Between Plasma Vitamin C and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization Study
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DOI: 10.3389/fmed.2022.844228
Abstract: Background Considering the antioxidant function of Vitamin C, also called ascorbic acid, it is widely used against viral infections such as coronavirus disease (COVID-19) based on in vitro, observational, and ecological studies. Many confounding factors… read more here.
Keywords: covid susceptibility; plasma vitamin; severity; vitamin ... See more keywords