Discovery of novel pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation
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DOI: 10.1002/ardp.202200395
Abstract: Searching for effective and selective anti‐inflammatory agents, our study involved designing and synthesizing new pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives 4–11. The structures of the synthesized derivatives were confirmed using different spectroscopic techniques. Virtual screening was achieved… read more here.
Keywords: pyrazole pyrazolo; cox; pyrazolo pyrimidine; cox cox ... See more keywords
Evaluation of the oral administration of α‐l‐guluronic acid on COX‐1 and COX‐2 gene expression profile in ankylosing spondylitis patients
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DOI: 10.1002/ddr.21756
Abstract: Ankylosing spondylitis (AS) is a chronic autoimmune arthritis disease with a genetic background, affecting the skeletal axis, sacroiliac, and peripheral joints. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the first‐line treatment for AS to alleviate the inflammation… read more here.
Keywords: cox; cox cox; gene expression; ankylosing spondylitis ... See more keywords
Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system
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DOI: 10.1111/bph.14167
Abstract: Eicosanoids represent a diverse family of lipid mediators with fundamental roles in physiology and disease. Within the eicosanoid superfamily are prostanoids, which are specifically derived from arachidonic acid by the enzyme cyclooxygenase (COX). COX has… read more here.
Keywords: eicosanoids prostacyclin; prostacyclin cyclooxygenase; cox; cardiovascular system ... See more keywords
Biological Evaluation and Molecular Docking Studies of Novel 1,3,4-Oxadiazole Derivatives of 4,6-Dimethyl-2-sulfanylpyridine-3-carboxamide
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DOI: 10.3390/ijms23010549
Abstract: To date, chronic inflammation is involved in most main human pathologies such as cancer, and autoimmune, cardiovascular or neurodegenerative disorders. Studies suggest that different prostanoids, especially prostaglandin E2, and their own synthase (cyclooxygenase enzyme-COX) can… read more here.
Keywords: biological evaluation; molecular docking; evaluation molecular; cox cox ... See more keywords
Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin
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DOI: 10.3390/ph10020050
Abstract: Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group. Herein, we describe in silico studies and… read more here.
Keywords: chiral derivatives; cyclooxygenases cox; inhibition; cox ... See more keywords
Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature
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DOI: 10.3390/ph11040101
Abstract: Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of cyclooxygenases (particularly COX-2) and prostaglandins (particularly PGE2) in cancer-related inflammation has… read more here.
Keywords: chemistry; cyclooxygenase cox; cox; cancer ... See more keywords