Design, Synthesis, and Biological Evaluation of Dual-Target COX-2/CYP51 Inhibitors for the Treatment of Fungal Infectious Diseases.
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DOI: 10.1021/acs.jmedchem.2c00878
Abstract: The design of novel dual-target (COX-2/CYP51) inhibitors was proposed in the study, and three series of compounds were constructed though the pathway of skeleton screening and combination; their molecular structures were synthesized and evaluated. Most… read more here.
Keywords: target cox; cyp51 inhibitors; cox cyp51; dual target ... See more keywords