CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine
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DOI: 10.1124/dmd.121.000624
Abstract: The primary mode of metabolism of nicotine is via the formation of cotinine by the enzyme CYP2A6. Cotinine undergoes further CYP2A6-mediated metabolism by hydroxylation to 3-hydroxycotinine and norcotinine, but can also form cotinine-N-glucuronide and cotinine-N-oxide… read more here.
Keywords: oxidation; cox formation; genetic variants; cotinine ... See more keywords