Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01807
Abstract: When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity… read more here.
Keywords: cox inhibitor; inhibitor hybrids; fluconazole cox; class ... See more keywords
Evaluation of the Genotoxic Potential of the Selective COX-2 Inhibitor Enflicoxib in a Battery of in vitro and in vivo Genotoxicity Assays
Sign Up to like & getrecommendations! Published in 2022 at "Drug Research"
DOI: 10.1055/a-1727-5733
Abstract: Aim Enflicoxib, a selective COX-2 inhibitor approved for the treatment of pain and inflammation associated with osteoarthritis in dogs (Daxocox ® [Ecuphar/Animalcare Group]) was assessed for its genotoxic potential in a battery of in vitro… read more here.
Keywords: vitro; genotoxic potential; vivo; battery vitro ... See more keywords
Expression of COX-2 and 15-PGDH in adenomas removed during pretreatment colonoscopy to predict chemopreventive efficacy of the selective COX-2 inhibitor, celecoxib.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.524
Abstract: 524Background: The APC trial showed that patients at high risk for colorectal adenoma development experienced a 33-45% reduction in post-polypectomy adenoma detection when treated with the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib. Unfortunately, this study also… read more here.
Keywords: inhibitor celecoxib; pgdh; cox; expression ... See more keywords