Synthesis, molecular docking, and pharmacological evaluation of N‐(2‐(3,5‐dimethoxyphenyl)benzoxazole‐5‐yl)benzamide derivatives as selective COX‐2 inhibitors and anti‐inflammatory agents
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DOI: 10.1002/ardp.201800008
Abstract: A series of N‐(2‐(3,5‐dimethoxyphenyl)benzoxazole‐5‐yl)benzamide derivatives (3am) was synthesized and evaluated for their in vitro inhibitory activity against COX‐1 and COX‐2. The compounds with considerable in vitro activity (IC50 read more here.
Keywords: anti inflammatory; cox inhibitors; dimethoxyphenyl benzoxazole; cox ... See more keywords
Efficacy and safety of selective COX-2 inhibitors for pain management after third molar removal: a meta-analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02910-3
Abstract: Objectives To compare selective COX-2 inhibitors with ibuprofen in terms of analgesia, rescue medication consumption, and adverse effects after impacted third molar removal. Materials and methods Electronic databases were searched. Single dose, double-blind, randomized, and… read more here.
Keywords: selective cox; cox inhibitors; third molar; molar removal ... See more keywords
Risk of perioperative bleeding related to highly selective cyclooxygenase-2 inhibitors: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2016.07.008
Abstract: BACKGROUND Several literatures reported that highly selective cycloxygenase-2 inhibitors (COX-2 inhibitors) had no effect on platelet function. However, some experts suggested stopping all non-steroidal anti-inflammatory drugs (NSAIDs), including COX-2 inhibitors at least five elimination half-lives… read more here.
Keywords: risk; highly selective; cox inhibitors; platelet ... See more keywords
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
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DOI: 10.1021/acsomega.3c00692
Abstract: Innate inflammation beyond a threshold is a significant problem involved in cardiovascular diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are key inflammatory markers as they catalyze prostaglandins production and are crucial for… read more here.
Keywords: inhibitors current; design development; cox inhibitors; cox ... See more keywords
Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants
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DOI: 10.1038/s41598-021-92120-3
Abstract: Congenital toxoplasmosis is represented by the transplacental passage of Toxoplasma gondii from the mother to the fetus. Our studies demonstrated that T. gondii developed mechanisms to evade of the host immune response, such as cyclooxygenase… read more here.
Keywords: trophoblast cells; cells villous; cox inhibitors; human trophoblast ... See more keywords
Molecular hybrid design, synthesis and biological evaluation of N-phenyl sulfonamide linked N-acyl hydrazone derivatives functioning as COX-2 inhibitors: new anti-inflammatory, anti-oxidant and anti-bacterial agents
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DOI: 10.1039/c7nj03332j
Abstract: Herein, we report the design, synthesis and biological evaluation of the anti-inflammatory activities of N-phenyl sulfonamide linked N-acylhydrazones (NPS–NAH), using the molecular hybridization approach. Hybrid compounds were further validated by theoretical studies. Compound 1f from… read more here.
Keywords: anti inflammatory; design synthesis; phenyl sulfonamide; anti bacterial ... See more keywords
Docking-based 3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) study on hydroquinoline and thiazinan-4-one derivatives as selective COX-2 inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1502687
Abstract: Abstract A series of 26 selective COX-2 inhibitors which reported previously by our laboratory was selected to generate three-dimensional quantitative structure activity relationship (3D-QSAR) model. Active conformation of each molecule was predicted by docking studies… read more here.
Keywords: comfa comfa; selective cox; comfa; cox inhibitors ... See more keywords
Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)
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DOI: 10.1080/13543776.2019.1623880
Abstract: ABSTRACT Introduction: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis. The products of this enzyme could play a major role as the mediators of the inflammatory response and some other medical… read more here.
Keywords: selective cox; anticancer agents; cox inhibitors; cox ... See more keywords
Current and emerging COX inhibitors for treating postoperative pain following oral surgery
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2161364
Abstract: ABSTRACT Introduction The numerous drugs in the NSAID class are often used to treat acute postoperative pain associated with oral surgery such as impacted third-molar extractions. These drugs are effective in this setting and dental… read more here.
Keywords: cox inhibitors; following oral; postoperative pain; pain ... See more keywords
Non-steroidal anti-inflammatory drugs and the risk of out-of-hospital cardiac arrest: a case–control study
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DOI: 10.1093/europace/euy180
Abstract: Abstract Aims Non-steroidal anti-inflammatory drugs (NSAIDs), particularly selective COX-2 inhibitors, are associated with an increased risk of cardiovascular adverse events. However, the association between these drugs and out-of-hospital cardiac arrest with electrocardiogram-documented ventricular tachycardia/ventricular fibrillation… read more here.
Keywords: selective cox; cox inhibitors; study; case ... See more keywords
Bullous Reactions Associated With COX-2 Inhibitors.
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DOI: 10.1097/mjt.0000000000000569
Abstract: CASE REPORTA 52-year-old man presented with a rash, which had been present for 2 days before his clinic visit. The rash developed 8 days after inception of oral treatment with etoricoxib, 60 mg o.d. for… read more here.
Keywords: bullous reactions; reactions associated; cox inhibitors; associated cox ... See more keywords