Trimethoxyphenyl containing compounds: Synthesis, biological evaluation, nitric oxide release, modeling, histochemical and histopathological studies.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105806
Abstract: Novel series of trimethoxy phenyl containing chalcone 3, 5, 6, 7, pyrazoline 4a&b, 9a-h and pyrazole 10a&b scaffolds were designed and synthesized. They were characterized by spectral data and elemental analyses. All newly synthesized compounds… read more here.
Keywords: trimethoxyphenyl containing; activity; inhibitory activity; cox inhibitory ... See more keywords
Racemic xanthine and dihydroxydopamine conjugates from Cyclopelta parva and their COX-2 inhibitory activity.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104534
Abstract: Seven new compounds including three pairs of enantiomeric xanthine analogues (1-3), a pair of enantiomeric hypoxanthine analogue (4), and three pairs of enantiomeric N-acetyldopamine dimers (6-8), together with a known one (5) (Fig. 1) were… read more here.
Keywords: racemic xanthine; cox inhibitory; cyclopelta parva;
Application of per-residue energy decomposition to identify the set of amino acids critical for in silico prediction of COX-2 inhibitory activity
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04944
Abstract: The enormous magnitude of scientific research carried out in the field of NSAIDs and cyclooxygenases (COXs) is known. They are crucial in pain management. COX-2 inhibitors have evolved over the years; from traditional NSAIDs to… read more here.
Keywords: inhibitory activity; amino acids; cox inhibitory; energy ... See more keywords
Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112970
Abstract: Hypericum monogynum L. (Hypericaceae) has been used as a folk Chinese medicine for the treatment of inflammatory related diseases. Cyclooxygenase-2 (COX-2) is a crucial target for the development of agents to treat inflammation. To search… read more here.
Keywords: hypericum monogynum; inhibitory activity; inhibitory; cox inhibitory ... See more keywords
(+/-)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02840
Abstract: (±)-Lucidumone (1), an enantiomeric meroterpenoid possessing an unprecedented skeleton comprising a fused 6/5/6/6/5 polycyclic system, was isolated from Ganoderma lucidum and structurally identified. The absolute configuration of (-)-1 was assigned by single-crystal X-ray crystallography. A… read more here.
Keywords: lucidumone cox; inhibitory caged; cox inhibitory; meroterpenoid ... See more keywords
Chemical Constituents of the Aerial Part of Valeriana officinalis var. latifolia Miq. With COX-2 Inhibitory Activity
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Communications"
DOI: 10.1177/1934578x221078628
Abstract: Twelve compounds, including a new iridoid (1) and 11 known compounds, were obtained from the aerial part of Valeriana officinalis var. latifolia Miq. Their structures were assigned by spectroscopic and mass spectrometric methods. All isolates… read more here.
Keywords: cox inhibitory; valeriana officinalis; part valeriana; inhibitory activity ... See more keywords