Exploring the molecular approach of COX and LOX in Alzheimer's and Parkinson's disorder.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-06033-x
Abstract: Neuroinflammation is well established biomarker for the major neurodegenerative like Alzheimer's disease (AD) and Parkinson's disease (PD). Cytokines/chemokines excite phospholipase A2 and cyclooxygenases (COX), facilitating the release of arachidonic acid (AA) and docosahexaenoic acid (DHA)… read more here.
Keywords: lox pathway; parkinson; role; acid ... See more keywords
Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.011
Abstract: A series of newly synthesized 4-aryl-hydrazonopyrazolones were designed and their structures were confirmed by spectral and elemental analyses. All synthesized compounds were evaluated for their in vitro COXs, 5-LOX inhibition, in vivo analgesic and anti-inflammatory… read more here.
Keywords: anti inflammatory; inflammatory activity; inflammatory; analgesic anti ... See more keywords
Safer anti‐inflammatory therapy through dual COX‐2/5‐LOX inhibitors: A structure‐based approach
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.06.003
Abstract: &NA; Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings. Chronic inflammation is associated with the pathogenesis and progression of cancer,… read more here.
Keywords: anti inflammatory; safer anti; inflammatory agents; cox ... See more keywords
Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2145283
Abstract: Abstract Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective antibacterial activity… read more here.
Keywords: cox; cox lox; activity cox; profile ... See more keywords
Effect of Hydro Alcoholic Extracts of Boswellia serrata and Terminalia bellerica Against Cyclo-Oxygenase and Lipoxygenase Enzymes- An In Vitro Approach
Sign Up to like & getrecommendations! Published in 2017 at "Phytopathology"
DOI: 10.25258/phyto.v9i08.9613
Abstract: Introduction: Inflammation is a key mediator in plenty of important physiological abnormalities like cancer, myocardial infarction and arthritis. Natural anti-inflammatory agents are of great demand owing to its decreased side effects and increased curative properties.… read more here.
Keywords: boswellia serrata; different concentrations; effect; terminalia bellerica ... See more keywords
Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1287570
Abstract: Cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) are overexpressed in gastric cancer cells, the dual inhibitors of which exhibit potential against metastasis and invasion with fewer side effects. To discover inhibitors targeting COX-2 and 5-LOX, we… read more here.
Keywords: cancer cells; gastric cancer; cox lox;
Sulfadiazine Exerts Potential Anticancer Effect in HepG2 and MCF7 Cells by Inhibiting TNFα, IL1b, COX-1, COX-2, 5-LOX Gene Expression: Evidence from In Vitro and Computational Studies
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceuticals"
DOI: 10.3390/ph17020189
Abstract: Drug repurposing is a promising approach that has the potential to revolutionize the drug discovery and development process. By leveraging existing drugs, we can bring new treatments to patients more quickly and affordably. Anti-inflammatory drugs… read more here.
Keywords: cox lox; effect; il1b cox; cox ... See more keywords
Unveiling Anticancer Potential of COX-2 and 5-LOX Inhibitors: Cytotoxicity, Radiosensitization Potential and Antimigratory Activity against Colorectal and Pancreatic Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics16060826
Abstract: Apart from cytotoxicity, inhibitors of the COX-2 enzyme have demonstrated additional effects important for cancer treatment (such as radiosensitization of tumor cells and cell antimigratory effects); however, the relationship between the inhibition of other inflammation-related… read more here.
Keywords: lox inhibitors; cell; cell line; cox lox ... See more keywords
[Retracted] Dual inhibition of COX‑2/5‑LOX blocks colon cancer proliferation, migration and invasion in vitro
Sign Up to like & getrecommendations! Published in 2024 at "Oncology Reports"
DOI: 10.3892/or.2024.8845
Abstract: Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that there appeared to be a number of anomalies in the presentation of data, including both tabulated… read more here.
Keywords: oncology; dual inhibition; cox lox; oncology reports ... See more keywords