Exploring the molecular approach of COX and LOX in Alzheimer's and Parkinson's disorder.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-06033-x
Abstract: Neuroinflammation is well established biomarker for the major neurodegenerative like Alzheimer's disease (AD) and Parkinson's disease (PD). Cytokines/chemokines excite phospholipase A2 and cyclooxygenases (COX), facilitating the release of arachidonic acid (AA) and docosahexaenoic acid (DHA)… read more here.
Keywords: lox pathway; parkinson; role; acid ... See more keywords
Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.011
Abstract: A series of newly synthesized 4-aryl-hydrazonopyrazolones were designed and their structures were confirmed by spectral and elemental analyses. All synthesized compounds were evaluated for their in vitro COXs, 5-LOX inhibition, in vivo analgesic and anti-inflammatory… read more here.
Keywords: anti inflammatory; inflammatory activity; inflammatory; analgesic anti ... See more keywords
Safer anti‐inflammatory therapy through dual COX‐2/5‐LOX inhibitors: A structure‐based approach
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.06.003
Abstract: &NA; Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings. Chronic inflammation is associated with the pathogenesis and progression of cancer,… read more here.
Keywords: anti inflammatory; safer anti; inflammatory agents; cox ... See more keywords
Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2145283
Abstract: Abstract Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective antibacterial activity… read more here.
Keywords: cox; cox lox; activity cox; profile ... See more keywords
Effect of Hydro Alcoholic Extracts of Boswellia serrata and Terminalia bellerica Against Cyclo-Oxygenase and Lipoxygenase Enzymes- An In Vitro Approach
Sign Up to like & getrecommendations! Published in 2017 at "Phytopathology"
DOI: 10.25258/phyto.v9i08.9613
Abstract: Introduction: Inflammation is a key mediator in plenty of important physiological abnormalities like cancer, myocardial infarction and arthritis. Natural anti-inflammatory agents are of great demand owing to its decreased side effects and increased curative properties.… read more here.
Keywords: boswellia serrata; different concentrations; effect; terminalia bellerica ... See more keywords