Activation of the COX-2/mPGES-1/PGE-2 cascade through the NLRP3 inflammasome contributes to Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis
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DOI: 10.1007/s00436-025-08454-8
Abstract: Prostaglandin E2 (PGE-2) is synthesised by cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1). PGE-2 exhibits pro-inflammatory properties in inflammatory conditions. However, there remains limited understanding of the COX-2/mPGES-1/PGE-2 pathway in Angiostrongylus cantonensis-induced meningoencephalitis.… read more here.
Keywords: cox; cantonensis; meningoencephalitis; nlrp3 inflammasome ... See more keywords
Up‐regulation of COX‐2 and mPGES‐1 by 27‐hydroxycholesterol and 4‐hydroxynonenal: A crucial role in atherosclerotic plaque instability
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DOI: 10.1016/j.freeradbiomed.2018.09.046
Abstract: &NA; Atherosclerosis is currently understood to be mainly the consequence of a complicated inflammatory process at the different stages of plaque development. Among the several inflammatory molecules involved, up‐regulation of the functional cyclooxygenase 2/membrane‐bound prostaglandin… read more here.
Keywords: cox mpges; plaque instability; regulation;