ROS-Mediated COXI Overexpression by AMPKα Confers Resistance to Dimefluthrin and Cross-Resistance to Indoxacarb in Aedes albopictus.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c03259
Abstract: Increased electron respiratory chain complex and Na+, K+-ATPase activity, ROS content, COXI and AMPKα expression, and decreased free ATP content were detected in a dimefluthrin-resistant Aedes albopictus (Ae. albopictus) strain established in laboratory, which developed… read more here.
Keywords: resistance; indoxacarb; coxi; resistance dimefluthrin ... See more keywords
Sodium Nitrate Improves Oxidative Energy Contribution and Reduces Phosphocreatine Contribution During High-Intensity Intermittent Exercise
Sign Up to like & getrecommendations! Published in 2024 at "Research Quarterly for Exercise and Sport"
DOI: 10.1080/02701367.2024.2396146
Abstract: ABSTRACT The present study aimed to verify the effect of acute nitrate supplementation on oxidative, phosphocreatine, and glycolytic energy contribution (COXI, CPCr, and CLAC, respectively) during a high-intensity intermittent exercise (HIIE). Fifteen physically active subjects… read more here.
Keywords: contribution; cpcr; coxi; exercise ... See more keywords
Cyclooxygenase inhibitor use during checkpoint blockade immunotherapy and effect on time to progression for metastatic melanoma patients.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e21029
Abstract: e21029 Background: In tumors, cyclooxygenase (COX) activity leads to biosynthesis of prostaglandin E2 which can inhibit T-cell and dendritic cell function, thereby allowing immune evasion. Preclinical models have shown therapeutic synergy between COX inhibitors (COXi)… read more here.
Keywords: metastatic melanoma; melanoma; checkpoint blockade; use ... See more keywords