pH-responsive carboxymethyl chitosan-derived micelles as apatinib carriers for effective anti-angiogenesis activity: Preparation and in vitro evaluation.
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DOI: 10.1016/j.carbpol.2017.08.011
Abstract: In this study, carboxymethyl chitosan-graft-poly-(ε-caprolactone) copolymers (CMCS-g-PCL) were synthesized and used to encapsulate apatinib to prepare apatinib-loaded CMCS-g-PCL (CPA) micelles. CPA micelles' sizes were 100-150nm at pH 7.4 while aggregated to 300-350nm at pH 6.4,… read more here.
Keywords: cpa micelles; carboxymethyl chitosan; anti angiogenesis; cmcs pcl ... See more keywords