Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop
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DOI: 10.1038/s41598-022-09595-x
Abstract: Genetic mutations in pancreatic digestive enzymes may cause protein misfolding, endoplasmic reticulum (ER) stress and chronic pancreatitis. The CPA1 N256K mouse model carries the human p.N256K carboxypeptidase A1 (CPA1) mutation, a classic example of a… read more here.
Keywords: ddit3; mice; chronic pancreatitis; cpa1 n256k ... See more keywords