Cys2His2 zinc finger methyl-CpG binding proteins: Getting a handle on methylated DNA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.012
Abstract: DNA methylation is an essential epigenetic modification involved in the maintenance of genomic stability, preservation of cellular identity, and regulation of the transcriptional landscape needed to maintain cellular function. In an increasing number of disease… read more here.
Keywords: binding proteins; dna; zinc finger; methyl cpg ... See more keywords
The Methyl-CpG Binding Domain 2 and 3 proteins and formation of the Nucleosome Remodeling and Deacetylase complex.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.10.007
Abstract: The Nucleosome Remodeling and Deacetylase (NuRD) complex uniquely combines both deacetylase and remodeling enzymatic activities in a single macromolecular complex. The Methyl-CpG Binding Domain 2 and 3 (MBD2 and MBD3) proteins provide a critical structural… read more here.
Keywords: deacetylase; binding domain; remodeling deacetylase; methyl cpg ... See more keywords
Methyl-CpG-binding domain 3 inhibits stemness of pancreatic cancer cells via Hippo signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112091
Abstract: Methyl-CpG-binding domain 3 (MBD3), as an induced stem cells reprogramming barrier, has an abnormal expression in various prevalent malignancies. However, in pancreatic cancer cell stemness, the roles of MBD3 remain unclear. In our study, the… read more here.
Keywords: methyl cpg; pancreatic cancer; cpg binding; mbd3 ... See more keywords
Expression regulation by a methyl-CpG binding domain in an E. coli based, cell-free TX-TL system.
Sign Up to like & getrecommendations! Published in 2017 at "Physical biology"
DOI: 10.1088/1478-3975/aa5d37
Abstract: Cytosine methylation plays an important role in the epigenetic regulation of eukaryotic gene expression. The methyl-CpG binding domain (MBD) is common to a family of eukaryotic transcriptional regulators. How MBD, a stretch of about 80… read more here.
Keywords: binding domain; methyl cpg; cell free; expression ... See more keywords
Abstract 130: CpG binding protein promotes cell proliferation through H3K4 methylation in ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-130
Abstract: E3 ubiquitin ligase CRL4 complex activation requires cullin neddylation. MLN4924, a NEDD8-activating enzyme (NAE) inhibitor, reportedly blocked cullin neddylation and inactivated cullin (CUL)-RING E3 ligases (CRLs). Studies have shown that MLN4924 inhibits cell proliferation and… read more here.
Keywords: cell proliferation; ovarian cancer; binding protein; cpg binding ... See more keywords
Rett syndrome: Methyl-CpG binding protein 2 transformation and phenotypic-genotypic characteristics
Sign Up to like & getrecommendations! Published in 2020 at "Pesquisa Agropecuaria Brasileira"
DOI: 10.19045/bspab.2020.90246
Abstract: Methyl-CpG-binding protein 2 (MECP2) mutation has been coupled to Rett syndrome; X-linked neurological disorder, leading to steady slowing down of neurodevelopment that exclusively affects girls worldwide. As this gene is known for its specific localization… read more here.
Keywords: methyl cpg; phenotypic; rett syndrome; cpg binding ... See more keywords
The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology
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DOI: 10.3390/cancers15102683
Abstract: Simple Summary Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein that is mainly studied for its role as an epigenetic regulator of gene transcription. Gene mutations affecting the function or expression level of this… read more here.
Keywords: biology; cpg binding; methyl cpg; mecp2 ... See more keywords
Methyl-CpG Binding Protein 2 in Alzheimer Dementia
Sign Up to like & getrecommendations! Published in 2019 at "International Neurourology Journal"
DOI: 10.5213/inj.1938196.098
Abstract: Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2) is an important epigenetic regulator… read more here.
Keywords: alzheimer disease; methyl cpg; disease; cpg binding ... See more keywords