Functional relevance of promoter CpG island of human Angiotensin II type 1 receptor (AT1R) gene
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03509-8
Abstract: Angiotensin II type 1 receptor can activate number of signalling pathways upon stimulation and consequently its involvement in cancer progression have also been revealed. But which epigenetic mechanisms are involved in its regulation, need to… read more here.
Keywords: cpg island; promoter cpg; promoter; gene ... See more keywords
DNA methylation at CpG island shore and RXRα regulate NR2F2 in heart tissues of tetralogy of Fallot patients.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.110
Abstract: The nuclear receptor subfamily 2 group F member 2 (NR2F2) gene encodes a ligand-inducible transcription factor involved in angiogenesis and heart development. This study aimed to elucidate the molecular mechanism of epigenetic regulation of NR2F2… read more here.
Keywords: island shore; methylation; cpg island; rxr ... See more keywords
Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.07.008
Abstract: BACKGROUND: CpG island methylator phenotype (CIMP) tumors, comprising 20% of colorectal cancers, are associated with female sex, age, right-sided location, and BRAF mutations. However, other factors potentially associated with CIMP have not been robustly examined.… read more here.
Keywords: colorectal cancer; cpg island; molecular characteristics; meta analysis ... See more keywords
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09828-0
Abstract: Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs… read more here.
Keywords: cancer; methylation; hypermethylation; cpg island ... See more keywords
A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
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DOI: 10.1038/s41467-021-22720-0
Abstract: CpG Island promoter genes make up more than half of human genes, and a subset regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI) become DNA hypermethylated and silenced in cancer. Here, we perform a systematic analysis of… read more here.
Keywords: prc2 cgi; cpg island; cancer; cgi genes ... See more keywords
CGIDLA:Developing the Web Server for CpG Island Related Density and LAUPs (Lineage-Associated Underrepresented Permutations) Study
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2935971
Abstract: It is well known that CpG island plays an important role in gene methylation. Since CpG island is closely related to human genetic characteristics such as TATA-box, tissue expression specificity, and LAUPs (Lineage-associated Underrepresented Permutations),… read more here.
Keywords: island; lineage associated; density; cpg island ... See more keywords
Interaction between the HIF‐1α gene rs1957757 polymorphism and CpG island methylation in the promoter region is associated with the risk of anti‐tuberculosis drug‐induced liver injury in humans: A case–control study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13625
Abstract: HIF‐1α gene polymorphisms, including rs11549465, rs11549467, rs1957757 and rs10873142, cause liver cell damage or pulmonary disease. The aim of this study was to analyse the association between the polymorphisms of the loci of the HIF‐1α… read more here.
Keywords: hif gene; cpg island; island methylation; methylation promoter ... See more keywords
GADD45A Recruits Demethylation Proteins to CpG Island Promoters.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-009
Abstract: GADD45A binding to R-loops promotes TET1 recruitment and DNA demethylation at CpG island promoters. read more here.
Keywords: cpg island; recruits demethylation; island promoters; gadd45a recruits ... See more keywords
CpG Island Methylator Phenotype May Predict Poor Overall Survival of Patients with Stage IV Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology"
DOI: 10.1159/000493387
Abstract: Objective: We aimed to study the prognostic role of CpG island methylator phenotype (CIMP) in patients with different stages of colorectal cancer (CRC). Material and Methods: We analyzed CIMP in stage I–IV CRC specimens from… read more here.
Keywords: cimp; cpg island; island methylator; crc ... See more keywords
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02343-7
Abstract: Background The ESR 1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of… read more here.
Keywords: cancer; methylation; cpg island; methylation levels ... See more keywords
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Epigenetics"
DOI: 10.1186/s13148-017-0347-1
Abstract: BackgroundThe CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine whether CIMP status in the primary… read more here.
Keywords: status; cimp; island methylator; cpg island ... See more keywords