Whole genome comparative analysis of CpG islands in camelid and other mammalian genomes
Sign Up to like & getrecommendations! Published in 2019 at "Mammalian Biology"
DOI: 10.1016/j.mambio.2019.07.007
Abstract: Camels bear unique genotypes and phenotypes for adaptation in their environment, and as such could be very useful in the weather extremes accelerated by global climate change. Published sequences of Camelidae genomes provide an opportunity… read more here.
Keywords: whole genome; mammalian genomes; cgi; cgis ... See more keywords
Implications of CpG islands on chromosomal architectures and modes of global gene regulation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky147
Abstract: Abstract CpG islands (CGIs) have long been implicated in the regulation of vertebrate gene expression. However, the involvement of CGIs in chromosomal architectures and associated gene expression regulations has not yet been thoroughly explored. By… read more here.
Keywords: gene regulation; cpg islands; chromosomal architectures; global gene ... See more keywords
MethyMer: Design of combinations of specific primers for bisulfite sequencing of complete CpG islands
Sign Up to like & getrecommendations! Published in 2018 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720018400048
Abstract: We present MethyMer, a Python-based tool aimed at selecting primers for amplification of complete CpG islands. These regions are difficult in terms of selecting appropriate primers because of their low-complexity, high GC content. Moreover, bisulfite… read more here.
Keywords: cpg islands; primers bisulfite; complete cpg; design combinations ... See more keywords
DNA Methylation Status of SHOX-Flanking CpG Islands in Healthy Individuals and Short Stature Patients with Pseudoautosomal Copy Number Variations
Sign Up to like & getrecommendations! Published in 2019 at "Cytogenetic and Genome Research"
DOI: 10.1159/000500468
Abstract: SHOX resides in the short arm pseudoautosomal region (PAR1) of the sex chromosomes and escapes X inactivation. SHOX haploinsufficiency underlies idiopathic short stature (ISS) and Leri-Weill dyschondrosteosis (LWD). A substantial percentage of cases with SHOX… read more here.
Keywords: shox flanking; cpg islands; flanking cpg; shox ... See more keywords
Clustered protocadherins methylation alterations in cancer
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DOI: 10.1186/s13148-019-0695-0
Abstract: BackgroundClustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- and γ-PCDH. The expression of this cluster consists of a complex mechanism involving DNA hub formation through DNA-CCTC… read more here.
Keywords: methylation; cpg islands; methylation alterations; cancer clustered ... See more keywords
Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18608
Abstract: Klotho (KL) is described as an anti-aging gene because mutation of Kl gene leads to multiple pre-mature aging phenotypes and shortens lifespan in mice. Growing evidence suggests that an increase in KL expression may be… read more here.
Keywords: cpg islands; expression; compound; gene ... See more keywords
Intragenic CpG Islands and Their Impact on Gene Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.832348
Abstract: The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated… read more here.
Keywords: cpg islands; intragenic cpg; islands impact; gene ... See more keywords
CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126467
Abstract: Cytosine methylation within the 5′-C-phosphate-G-3′ sequence of nucleotides (called CpG methylation) is a well-known epigenetic modification of genomic DNA that plays an important role in gene expression and development. CpG methylation is likely to be… read more here.
Keywords: cpg islands; cpg methylation; methylation; structure ... See more keywords