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Published in 2022 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22496
Abstract: As popularised by PrediXcan (and related methods), transcriptome‐wide association studies (TWAS), in which gene expression is imputed from single‐nucleotide polymorphism (SNP) genotypes and tested for association with a phenotype, are a popular approach for investigating…
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Keywords:
cpg methylation;
methylation;
gene expression;
complex traits ... See more keywords
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Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111743
Abstract: Notch3 can act as a tumor suppressor in the breast cancer epithelial cells. Unfortunately, Notch3 expression is decreased or lost, especially in triple-negative breast cancer (TNBC) cells, and the reasons remain unclear. Here, we found…
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Keywords:
cpg methylation;
non cpg;
cpg;
breast cancer ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13256-9
Abstract: Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which…
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Keywords:
search epistatic;
epistatic effects;
exhaustive search;
effects human ... See more keywords
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Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2016-312742
Abstract: Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than for other viral infections.…
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Keywords:
response;
hbv;
methylation utr;
single cpg ... See more keywords
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Published in 2020 at "BMC Medical Genetics"
DOI: 10.1186/s12881-020-01142-7
Abstract: Background CpG methylation of tumor suppressor genes occurs in the early stage of carcinogenesis. Detecting risk factors for aberrant CpG methylation is clinically important for predicting cancer development. DNA methyltransferase (DNMT) 3a is considered to…
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Keywords:
rs6733868 rs13428812;
methylation;
gastric mucosa;
cpg ... See more keywords
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Published in 2018 at "Biology Open"
DOI: 10.1242/bio.034884
Abstract: ABSTRACT The placenta is a fetal exchange organ connecting mother and baby that facilitates fetal growth in utero. DNA methylation is thought to impact placental development and function. Global DNA methylation studies using human placental…
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Keywords:
methylation;
differences pattern;
global cpg;
cell ... See more keywords
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Published in 2020 at "Epigenomics"
DOI: 10.2217/epi-2019-0391
Abstract: Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal muscle, a major insulin-sensitive tissue responsible for glucose homeostasis. We determined whether transcriptional oscillations are associated with CpG methylation changes in skeletal muscle.…
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Keywords:
cpg methylation;
skeletal muscle;
methylation;
metabolism development ... See more keywords
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Published in 2017 at "Biomolecules"
DOI: 10.3390/biom7010015
Abstract: The process of DNA CpG methylation has been extensively investigated for over 50 years and revealed associations between changing methylation status of CpG islands and gene expression. As a result, DNA CpG methylation is implicated…
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Keywords:
methylation;
gene expression;
dna cpg;
expression ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222313159
Abstract: Genomic DNA methylation is involved in many diseases and is expected to be a specific biomarker for even the pre-symptomatic diagnosis of many diseases. Thus, a rapid and inexpensive detection method is required for disease…
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Keywords:
cpg methylation;
methylation;
methylation quadruplex;
detection ... See more keywords
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2
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126467
Abstract: Cytosine methylation within the 5′-C-phosphate-G-3′ sequence of nucleotides (called CpG methylation) is a well-known epigenetic modification of genomic DNA that plays an important role in gene expression and development. CpG methylation is likely to be…
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Keywords:
cpg islands;
cpg methylation;
methylation;
structure ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076179
Abstract: The regulatory role of non-CpG methylation in mammals has been important in whole-genome bisulfite sequencing. It has also been suggested that non-CpG methylation regulates gene expression to affect the development and health of mammals. However,…
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Keywords:
fzd7;
cpg methylation;
non cpg;
proliferation ... See more keywords