Articles with "cpg methylation" as a keyword



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Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits

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Published in 2022 at "Genetic Epidemiology"

DOI: 10.1002/gepi.22496

Abstract: As popularised by PrediXcan (and related methods), transcriptome‐wide association studies (TWAS), in which gene expression is imputed from single‐nucleotide polymorphism (SNP) genotypes and tested for association with a phenotype, are a popular approach for investigating… read more here.

Keywords: cpg methylation; methylation; gene expression; complex traits ... See more keywords
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The frequency of CpG and non-CpG methylation of Notch3 gene promoter determines its expression levels in breast cancer cells.

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Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.111743

Abstract: Notch3 can act as a tumor suppressor in the breast cancer epithelial cells. Unfortunately, Notch3 expression is decreased or lost, especially in triple-negative breast cancer (TNBC) cells, and the reasons remain unclear. Here, we found… read more here.

Keywords: cpg methylation; non cpg; cpg; breast cancer ... See more keywords
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Exhaustive search for epistatic effects on the human methylome

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Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-13256-9

Abstract: Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which… read more here.

Keywords: search epistatic; epistatic effects; exhaustive search; effects human ... See more keywords
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Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5′-UTR of TRIM22

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Published in 2017 at "Gut"

DOI: 10.1136/gutjnl-2016-312742

Abstract: Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than for other viral infections.… read more here.

Keywords: response; hbv; methylation utr; single cpg ... See more keywords
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Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa

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Published in 2020 at "BMC Medical Genetics"

DOI: 10.1186/s12881-020-01142-7

Abstract: Background CpG methylation of tumor suppressor genes occurs in the early stage of carcinogenesis. Detecting risk factors for aberrant CpG methylation is clinically important for predicting cancer development. DNA methyltransferase (DNMT) 3a is considered to… read more here.

Keywords: rs6733868 rs13428812; methylation; gastric mucosa; cpg ... See more keywords
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Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation

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Published in 2018 at "Biology Open"

DOI: 10.1242/bio.034884

Abstract: ABSTRACT The placenta is a fetal exchange organ connecting mother and baby that facilitates fetal growth in utero. DNA methylation is thought to impact placental development and function. Global DNA methylation studies using human placental… read more here.

Keywords: methylation; differences pattern; global cpg; cell ... See more keywords
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Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development.

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Published in 2020 at "Epigenomics"

DOI: 10.2217/epi-2019-0391

Abstract: Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal muscle, a major insulin-sensitive tissue responsible for glucose homeostasis. We determined whether transcriptional oscillations are associated with CpG methylation changes in skeletal muscle.… read more here.

Keywords: cpg methylation; skeletal muscle; methylation; metabolism development ... See more keywords
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The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer

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Published in 2017 at "Biomolecules"

DOI: 10.3390/biom7010015

Abstract: The process of DNA CpG methylation has been extensively investigated for over 50 years and revealed associations between changing methylation status of CpG islands and gene expression. As a result, DNA CpG methylation is implicated… read more here.

Keywords: methylation; gene expression; dna cpg; expression ... See more keywords
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Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands

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Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms222313159

Abstract: Genomic DNA methylation is involved in many diseases and is expected to be a specific biomarker for even the pre-symptomatic diagnosis of many diseases. Thus, a rapid and inexpensive detection method is required for disease… read more here.

Keywords: cpg methylation; methylation; methylation quadruplex; detection ... See more keywords
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CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands

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Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23126467

Abstract: Cytosine methylation within the 5′-C-phosphate-G-3′ sequence of nucleotides (called CpG methylation) is a well-known epigenetic modification of genomic DNA that plays an important role in gene expression and development. CpG methylation is likely to be… read more here.

Keywords: cpg islands; cpg methylation; methylation; structure ... See more keywords
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FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation

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Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076179

Abstract: The regulatory role of non-CpG methylation in mammals has been important in whole-genome bisulfite sequencing. It has also been suggested that non-CpG methylation regulates gene expression to affect the development and health of mammals. However,… read more here.

Keywords: fzd7; cpg methylation; non cpg; proliferation ... See more keywords