Immunoprotection induced by CpG‐ODN/Poly(I:C) combined with recombinant gp90 protein in chickens against reticuloendotheliosis virus infection
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.04.019
Abstract: Abstract The present study is focused on investigating the immunoprotective effects of CpG‐ODN/Poly(I:C) combined with the viral glycoprotein gp90 protein against reticuloendotheliosis virus (REV) infection in chickens. REV's gp90 gene was amplified from the REV‐infected… read more here.
Keywords: cpg odn; odn poly; protein; infection ... See more keywords
Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.048
Abstract: Although synthetic CpG oligodeoxynucleotides (ODNs) have shown substantial potential as immunotherapeutic agents, their effective intracellular delivery remains challenging. In this work, nanoparticles prepared from low-molecular weight (LMW) chitosans were investigated as CpG ODN delivery systems.… read more here.
Keywords: cpg odn; low molecular; delivery; molecular weight ... See more keywords
Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117067
Abstract: AIMS Both CpG oligodeoxynucleotide (CpG-ODN) and melatonin have been reported to induce Th1 response and contribute to allergic asthma resistance. Here, we aimed to reveal how they confer such effect as well as whether they… read more here.
Keywords: cpg odn; allergic airway; inflammation; airway inflammation ... See more keywords
Synthesis of protein conjugates adsorbed on cationic liposomes surface
Sign Up to like & getrecommendations! Published in 2020 at "MethodsX"
DOI: 10.1016/j.mex.2020.100942
Abstract: The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In… read more here.
Keywords: cpg odn; protein conjugates; chemistry; cationic liposomes ... See more keywords
TLR9 agonist suppresses choroidal neovascularization by restricting endothelial cell motility via ERK/c-Jun pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Microvascular research"
DOI: 10.1016/j.mvr.2022.104338
Abstract: INTRODUCTION Choroidal neovascularization (CNV) is the feature of neovascular age-related macular degeneration (AMD). It has been demonstrated that inflammation plays a key role in the development of CNV. Here we aim to investigate how TLR9… read more here.
Keywords: erk; cell; odn; cpg odn ... See more keywords
Polymeric antigen BLSOmp31 formulated with class B CpG-ODN in a nanostructure (BLSOmp31/CpG-ODN/Coa-ASC16) administered by parenteral or mucosal routes confers protection against Brucella ovis in Balb/c mice.
Sign Up to like & getrecommendations! Published in 2021 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2021.02.011
Abstract: Previously, we demonstrated that the chimera BLSOmp31 formulated in chitosan microspheres or Poloxamer407-Chitosan administered via the nasal and the ocular mucosa conferred partial protection in sheep against B. ovis. In this work, we tested a… read more here.
Keywords: cpg odn; coa asc16; cpg; blsomp31 cpg ... See more keywords
Recombinant Erns-E2 protein vaccine formulated with MF59 and CPG-ODN promotes T cell immunity against bovine viral diarrhea virus infection.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.03.020
Abstract: To obtain an effective vaccine candidate against bovine viral diarrhea virus (BVDV) disease which causes great economical loss in cattle industries, recombinant Erns-E2 protein vaccine containing MF59 and CPG-ODN adjuvants was prepared and assessed in… read more here.
Keywords: protein vaccine; cpg odn; recombinant erns; erns protein ... See more keywords
Evaluation of CpG-ODN-adjuvanted polyanhydride-based intranasal influenza nanovaccine in pigs.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2019.108401
Abstract: Influenza results in significant economic loss in the swine industry each year. A broadly protective swine influenza vaccine would have the dual benefit of protecting pigs from influenza A viruses (IAVs) and limiting their possible… read more here.
Keywords: cpg odn; cpg nanovaccine; kag cpg; kag ... See more keywords
PLGA-encapsulated CpG ODN and Campylobacter jejuni lysate modulate cecal microbiota composition in broiler chickens experimentally challenged with C. jejuni
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DOI: 10.1038/s41598-018-30510-w
Abstract: Campylobacter jejuni is a leading bacterial cause of human gastroenteritis. Reducing Campylobacter numbers in the intestinal tract of chickens will minimize transmission to humans, thereby reducing the incidence of infection. We have previously shown that… read more here.
Keywords: cpg odn; microbiota; jejuni; jejuni lysate ... See more keywords
CpG Oligodeoxynucleotides Inhibit RANKL-Induced Osteoclast Formation by Upregulating A20 Deubiquitinase in RAW 264.7 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/5255935
Abstract: Objective Activation of toll-like receptor 9 (TLR9) has been proposed to play an inhibitory role in RANKL-induced osteoclastogenesis. A20 deubiquitinase has been found to be related to bone loss. This study investigated the role of… read more here.
Keywords: 264 cells; rankl induced; rankl; raw 264 ... See more keywords
Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice
Sign Up to like & getrecommendations! Published in 2017 at "BMC Research Notes"
DOI: 10.1186/s13104-017-2380-8
Abstract: BackgroundTo overcome infectious diseases, the development of mucosal vaccines would be an effective strategy, since mucosal surfaces are the entry site for most pathogens. In general, protein antigens show inherently poor immunogenicity when administered by… read more here.
Keywords: cpg odn; dotap chol; mucosal;