Cationic polymers for enhancing CpG oligodeoxynucleotides-mediated cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2018.12.044
Abstract: Abstract Unmethylated cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) as an adjuvant can activate innate and adaptive immune responses and simultaneously produce a large number of proinflammatory cytokines and up-regulate costimulatory molecules to treat cancer, allergy, asthma and… read more here.
Keywords: cpg; cpg oligodeoxynucleotides; enhancing cpg; cancer ... See more keywords
Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.048
Abstract: Although synthetic CpG oligodeoxynucleotides (ODNs) have shown substantial potential as immunotherapeutic agents, their effective intracellular delivery remains challenging. In this work, nanoparticles prepared from low-molecular weight (LMW) chitosans were investigated as CpG ODN delivery systems.… read more here.
Keywords: cpg odn; low molecular; delivery; molecular weight ... See more keywords
CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17609-2
Abstract: Synthetic phosphorothiolate-modified CpG-oligodeoxynucleotides (CpG-ODNs) are potent immune stimuli. Toll-like receptor (TLR) 9 and TLR21 are their cellular receptors in different species. The structural requirements for CpG-ODN to strongly activate TLR9 have been relatively well studied,… read more here.
Keywords: toll like; cpg odns; cpg oligodeoxynucleotides; cpg ... See more keywords
Targeting of C‐type lectin‐like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13877
Abstract: We read with great interest the article by Delierneux et al. [1] in the Journal of Thrombosis and Haemostasis. The authors elegantly describe a mechanism of platelet activation by CpG oligodeoxynucleotides (ODNs) through CLEC-2 mediated binding… read more here.
Keywords: platelet activation; activation; receptor; cpg oligodeoxynucleotides ... See more keywords
The Toll-like receptor ligand, CpG oligodeoxynucleotides, regulate proliferation and osteogenic differentiation of osteoblast
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-020-01844-x
Abstract: Background This study aimed to investigate the regulation of CpG oligodeoxynucleotides (ODNs) on proliferation and osteogenic differentiation of MC3T3 cells. Methods The laser co-focusing and flow cytometry assay were employed to detect cell uptake of… read more here.
Keywords: proliferation osteogenic; osteogenic differentiation; differentiation; cpg oligodeoxynucleotides ... See more keywords
Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11111617
Abstract: Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type duplex/G4 ODNs as robust… read more here.
Keywords: topology; cpg odns; guanine quadruplex; cpg oligodeoxynucleotides ... See more keywords
CpG Oligodeoxynucleotides for Anticancer Monotherapy from Preclinical Stages to Clinical Trials
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010073
Abstract: CpG oligodeoxynucleotides (CpG ODNs), the artificial versions of unmethylated CpG motifs that were originally discovered in bacterial DNA, are demonstrated not only as potent immunoadjuvants but also as anticancer agents by triggering toll-like receptor 9… read more here.
Keywords: cpg; anticancer monotherapy; cpg odn; clinical trials ... See more keywords
Formulation of SARS-CoV-2 Spike Protein with CpG Oligodeoxynucleotides and Squalene Nanoparticles Modulates Immunological Aspects Following Intranasal Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112539
Abstract: Nasal spray vaccination is viewed as a promising strategy for inducing both mucosal and systemic protection against respiratory SARS-CoV-2 coronavirus. Toward this goal, a safe and efficacious mucosal adjuvant is necessary for the transportation of… read more here.
Keywords: cov spike; spike protein; cpg oligodeoxynucleotides; immunological aspects ... See more keywords