Extent, pattern, and prognostic value of MGMT promotor methylation: does it differ between glioblastoma and IDH-wildtype/TERT-mutated astrocytoma?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-021-03912-6
Abstract: The cIMPACT-NOW update 6 first introduced glioblastoma diagnosis based on the combination of IDH-wildtype (IDHwt) status and TERT promotor mutation (pTERTmut). In glioblastoma as defined by histopathology according to the WHO 2016 classification, MGMT promotor… read more here.
Keywords: glioblastoma; histopathology; mgmt promotor; cpg sites ... See more keywords
SU1 EXPLORING GENETIC VARIATION THAT INFLUENCES BRAIN METHYLATION IN ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD)
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.190
Abstract: Background Allele-Specific Methylation (ASM) is a common epigenetic mechanism that involves SNPs correlating with differential levels of methylation at CpG sites. Epigenetic changes play a crucial role in driving lasting changes in gene expression in… read more here.
Keywords: methylation; cpg sites; snps; brain ... See more keywords
Obese status is associated with accelerated DNA methylation change in peripheral blood of senior dogs.
Sign Up to like & getrecommendations! Published in 2021 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2021.07.024
Abstract: Obesity and its associated comorbidities constitute a major and growing health problem worldwide not only involved with people but also dogs and cats. Although few genetic mutations have been associated with obesity in dogs, molecular… read more here.
Keywords: methylation; cpg sites; change; differentially methylated ... See more keywords
Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10864-z
Abstract: In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. Current approaches to the association detection claim whether a cytosine-phosphate-guanine (CpG) site is associated with… read more here.
Keywords: detection; risk cpg; cpg sites; association ... See more keywords
The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04212-8
Abstract: Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly encountered in pluripotent stem cells (PSCs) and their differentiated progeny. Transgene expression in these cells,… read more here.
Keywords: cpg sites; ubiquitous chromatin; anti silencing; chromatin opening ... See more keywords
DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89279-0
Abstract: DNA methylation plays important functions in gene expression regulation that is involved in individual development and various diseases. DNA methylation has been well studied in human and model organisms, but only limited data exist in… read more here.
Keywords: methylation sensitive; methylation; dna methylation; cpg sites ... See more keywords
Epigenome-wide association study reveals CpG sites related to COG of neuroblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200826
Abstract: Abstract Background. Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children. Its variable location and complex pathogenesis make NB hard for early diagnosis and risk classification. Methodology. We analyzed the methylation… read more here.
Keywords: epigenome wide; association study; study; cog ... See more keywords
DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0042-1749328
Abstract: BACKGROUND Ischemic stroke (IS) risk heritability is partly explained by genetics. Other heritable factors, such as epigenetics, could explain an unknown proportion of the IS risk. The objective of this study is to evaluate DNA… read more here.
Keywords: cpg sites; epigenome wide; dna methylation; risk ... See more keywords
Methylation of Specific CpG Sites in IL-1β and IL1R1 Genes is Affected by Hyperglycaemia in Type 2 Diabetic Patients
Sign Up to like & getrecommendations! Published in 2019 at "Immunological Investigations"
DOI: 10.1080/08820139.2019.1656227
Abstract: ABSTRACT Objective: Type 2 diabetes (T2D), which is the most common metabolic disorder in the world, results from insulin resistance of target tissues and reduced production of insulin from pancreatic β cells with genetic and… read more here.
Keywords: methylation; cpg sites; il1r1 genes; type ... See more keywords
A comprehensive evaluation of alignment software for reduced representation bisulfite sequencing data
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty174
Abstract: Motivation The rapid development of next-generation sequencing technology provides an opportunity to study genome-wide DNA methylation at single-base resolution. However, depletion of unmethylated cytosines brings challenges for aligning bisulfite-converted sequencing reads to a large reference.… read more here.
Keywords: methylation; cpg sites; reduced representation; rrbssim ... See more keywords
The association between breast cancer and S100P methylation in peripheral blood by multicenter case–control studies
Sign Up to like & getrecommendations! Published in 2017 at "Carcinogenesis"
DOI: 10.1093/carcin/bgx004
Abstract: Breast cancer (BC) is the leading cancer in women worldwide. Changes in DNA methylation in peripheral blood could be associated with malignant diseases. Making use of screening results by llumina 27K Methylation Assay, we validated… read more here.
Keywords: methylation; cpg sites; case; blood ... See more keywords