Ultrasound enhances ZD2767P‒carboxypeptidase G2 against chemoresistant ovarian cancer cells by altering the intracellular pharmacokinetics of ZD2767D.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00008
Abstract: Prodrug‒carboxypeptidase G2 (e.g., ZD2767P+CPG2) can realize a targeted treatment where the specific advantage is a lack of CPG2 analogs in humans, but it is limited by low efficacy. Here ultrasound was employed to enhance ZD2767P+CPG2… read more here.
Keywords: cpg2; ovarian cancer; cancer cells; zd2767p cpg2 ... See more keywords
Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function
Sign Up to like & getrecommendations! Published in 2019 at "Molecular psychiatry"
DOI: 10.1038/s41380-018-0314-z
Abstract: Bipolar disorder (BD) is a common mood disorder characterized by recurrent episodes of mania and depression. Both genetic and environmental factors have been implicated in BD etiology, but the biological underpinnings remain elusive. Recently, genome-wide… read more here.
Keywords: protein; disorder; cpg2; expression ... See more keywords
P14.118 Carboxypeptidase G2 (CPG2) rescue after high dose methotrexate (hdMTX) chemotherapy for Primary CNS Lymphoma (PCNSL). A French LOC network study
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.353
Abstract: CPG2 is an efficient rescue recombinant bacterial enzyme that cleaves MTX into inactive metabolites. As hdMTX is the key agent in PCNSL, delayed MTX excretion (DME), and/or MTX induced nephrotoxicity (MIN) may expose the patients… read more here.
Keywords: loc network; cpg2; study; rescue ... See more keywords
Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy
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DOI: 10.3389/fonc.2023.1003633
Abstract: Introduction Glucarpidase (CPG2) reduces the lethal toxicity of methotrexate (MTX) by rapid degradation. Methods In this study, a CPG2 population pharmacokinetics (popPK) analysis in healthy volunteers (phase 1 study) and a popPK-pharmacodynamics (popPK-PD) analysis in… read more here.
Keywords: cpg2; mtx; methotrexate; population pharmacokinetics ... See more keywords