cPKCγ ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation/reoxygenation by inhibiting ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience research"
DOI: 10.1016/j.neures.2022.04.003
Abstract: Ferroptosis is an iron-dependent pathway of regulated cell death. But the exact mechanism of ferroptosis in ischemic stroke remains unclear. We hypothesize that conventional protein kinase cγ (cPKCγ) can attenuate neuronal death by regulating ferroptosis.… read more here.
Keywords: glucose deprivation; oxygen glucose; cpkc; ferroptosis ... See more keywords
Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca2+-dependent PKC activation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.03.016
Abstract: Statins, in addition to their cholesterol lowering effects, can prevent isoprenylation of Rab GTPase proteins, a key protein family for the regulation of protein trafficking. Rab-GTPases have been shown to be involved in the control… read more here.
Keywords: ca2 dependent; function; dependent pkc; cpkc ... See more keywords