[Carboxyl‐11C]Labelling of Four High‐Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700697
Abstract: Cytosolic phospholipase A2α (cPLA2α) may play a critical role in neuropsychiatric and neurodegenerative disorders associated with oxidative stress and neuroinflammation. An effective PET radioligand for imaging cPLA2α in living brain might prove useful for biomedical… read more here.
Keywords: four high; indole carboxylic; cpla2; carboxylic acid ... See more keywords
Targeting cPLA2α inhibits gastric cancer and augments chemotherapy efficacy via suppressing Ras/MEK/ERK and Akt/β-catenin pathways
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04322-1
Abstract: Cytosolic phospholipase A2alpha (cPLA2α), an enzyme that is responsible for the hydrolysis of membrane phospholipids, is a key mediator of tumor transformation, progression and metastasis. The role of cPLA2α in gastric cancer has not been… read more here.
Keywords: mek erk; gastric cancer; cpla2; cancer ... See more keywords
Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110802
Abstract: Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver… read more here.
Keywords: growth hormone; cpla2; expression; exposure growth ... See more keywords
The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aav5918
Abstract: Lipid-regulated production of eicosanoids by cPLA2α directs the behaviors of dermal fibroblasts during wound repair. Lipids set the pace for wound repair Wound repair proceeds through distinct phases. Hemostasis and inflammation are followed by proliferation… read more here.
Keywords: collagen; cpla2; wound repair; mice ... See more keywords
Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture
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DOI: 10.1128/jvi.01463-17
Abstract: ABSTRACT Coronavirus replication is associated with intracellular membrane rearrangements in infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other membranous structures that are referred to as replicative organelles (ROs). The latter provide… read more here.
Keywords: microscopy; cpla2; phospholipase; coronavirus ... See more keywords
Involvement of the γ Isoform of cPLA2 in the Biosynthesis of Bioactive N-Acylethanolamines
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26175213
Abstract: Arachidonylethanolamide (anandamide) acts as an endogenous ligand of cannabinoid receptors, while other N-acylethanolamines (NAEs), such as palmitylethanolamide and oleylethanolamide, show analgesic, anti-inflammatory, and appetite-suppressing effects through other receptors. In mammalian tissues, NAEs, including anandamide, are… read more here.
Keywords: biosynthesis; cpla2; involvement isoform; isoform cpla2 ... See more keywords
Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2α attenuates focal ischemic brain damage in mice
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8610
Abstract: Cerebral ischemia injury is a clinical, frequently occurring disease, which causes a heavy burden on society and families. It has been demonstrated that cytosolic phospholipase A2α (cPLA2α) is significant in neurological injury caused by ischemic… read more here.
Keywords: pad sirna; cpla2; rna interference; damage ... See more keywords
Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.346460
Abstract: Central nervous system (CNS) trauma, including traumatic brain injury and spinal cord injury, has a high rate of disability and mortality, and effective treatment is currently lacking. Previous studies have revealed that neural inflammation plays… read more here.
Keywords: cpla2; cytosolic phospholipase; cns trauma; central nervous ... See more keywords