In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00802
Abstract: Microglia play a role in several central nervous system (CNS) diseases and are a highly sought target for positron emission tomography (PET) imaging and therapeutic intervention. 5-Cyano-N-(4-(4-[11C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([11C]CPPC) is a radiopharmaceutical designed to selectively target… read more here.
Keywords: radioligand; evaluation cppc; tool; csf ... See more keywords
Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00924b
Abstract: Peptides constrained through multiple disulfides (or disulfide-rich peptides, DRPs) have been an emerging frontier for ligand and drug discovery. Such peptides have the potential to combine the binding capability of biologics with the stability and… read more here.
Keywords: structure; disulfide rich; peptide; discovery ... See more keywords
Pilot imaging of the colony stimulating factor 1 receptor in the brains of virally-suppressed individuals with HIV.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003572
Abstract: OBJECTIVE Neuroimmune activation is a putative driver of cognitive impairment in people with HIV (PWH), even in the age of modern antiretroviral therapy. Nevertheless, imaging of the microglial marker, the 18kDa translocator protein (TSPO), with… read more here.
Keywords: factor receptor; stimulating factor; 11c cppc; virally suppressed ... See more keywords