Purification of carbamoyl phosphate synthetase 1 (CPS1) from wood frog (Rana sylvatica) liver and its regulation in response to ice-nucleation and subsequent whole-body freezing
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3468-8
Abstract: Carbamoyl phosphate synthetase I (CPS1) represents an important regulatory enzyme of the urea cycle that mediates the ATP-driven reaction ligating ammonium, carbonate, and phosphate to form carbamoyl phosphate. The freeze-tolerant wood frog (Rana sylvatica or… read more here.
Keywords: wood frog; cps1; phosphate; carbamoyl phosphate ... See more keywords
In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1035-0
Abstract: Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer’s disease (AD), major… read more here.
Keywords: snps; glul; metabolism genes; cps1 ... See more keywords
Viable spores of Coccidioides posadasii Δcps1 are required for vaccination and provide long lasting immunity.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.04.026
Abstract: Coccidioidomycosis is a systemic fungal infection for which a vaccine has been sought for over fifty years. The avirulent Coccidioides posadasii strain, Δcps1, which is missing a 6 kb gene, showed significant protection in mice. These… read more here.
Keywords: vaccinated mice; immunity; coccidioides posadasii; cps1 ... See more keywords
Precision medicine in rare disease: Mechanisms of disparate effects of N-carbamyl-l-glutamate on mutant CPS1 enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2016.12.002
Abstract: This study documents the disparate therapeutic effect of N-carbamyl-l-glutamate (NCG) in the activation of two different disease-causing mutants of carbamyl phosphate synthetase 1 (CPS1). We investigated the effects of NCG on purified recombinant wild-type (WT)… read more here.
Keywords: medicine; carbamyl glutamate; cps1; mutant cps1 ... See more keywords
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06614-9
Abstract: The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene… read more here.
Keywords: expression; urea cycle; cycle; liver ... See more keywords
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040744
Abstract: Simple Summary Individual patients with liver cancer have a highly variable clinical course. Hence, there is an urgent need to identify new prognostic markers to determine prognosis and select specific therapies. Expression of two key… read more here.
Keywords: key enzymes; prognosis; cad; pyrimidine synthesis ... See more keywords
Construction of a Frequency Compliant Unit Commitment Framework Using an Ensemble Learning Technique
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DOI: 10.3390/en14020310
Abstract: Frequency control is essential to ensure reliability and quality of power systems. North American Electric Reliability Corporation’s (NERC) Control Performance Standard 1 (CPS1) is widely adopted by many operating authorities to examine the quality of… read more here.
Keywords: ensemble learning; unit commitment; frequency; learning technique ... See more keywords
Evidencing New Roles for the Glycosyl-Transferase Cps1 in the Phytopathogenic Fungus Botrytis cinerea
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8090899
Abstract: The fungal cell wall occupies a central place in the interaction between fungi and their environment. This study focuses on the role of the putative polysaccharide synthase Cps1 in the physiology, development and virulence of… read more here.
Keywords: botrytis cinerea; cell wall; cps1;