CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0424-1
Abstract: The post-genomic era has seen many advances inBaryza and G. Rice for helpful our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to target even monogenic tumors. Here, we combine phenotypic… read more here.
Keywords: mrna processing; ewing sarcoma; cpsf3; aml ewing ... See more keywords
Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0039
Abstract: Background: Recent studies have shown that cleavage and polyadenylation-specific factor 3 (CPSF3) is a promising antitumor therapeutic target, but its potential role in hepatocellular carcinoma (HCC) has not been reported. Materials & methods: We explored… read more here.
Keywords: cleavage polyadenylation; hcc; group; specific factor ... See more keywords