Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells
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DOI: 10.1002/2211-5463.12985
Abstract: Malignant mesothelioma (MM) is an aggressive malignant neoplasm which rapidly invades pleural tissues and has a poor prognosis. Here, we explore enhancement of the effect of irinotecan [camptothecin‐11 (CPT‐11)] by the p53‐dependent induction of carboxylesterase… read more here.
Keywords: use irinotecan; cpt; mesothelioma; p53 ... See more keywords
SENP1 participates in Irinotecan resistance in human colon cancer cells
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DOI: 10.1002/jcb.29946
Abstract: Colorectal cancer is one of the most prevalent cancers in the world. Chemoresistance has always been a problem encountered in its treatment. It is known that SUMOylation may regulate protein stability and decomposition, and even… read more here.
Keywords: senp1; cpt; colorectal cancer; human colon ... See more keywords
Clinical outcomes for COVID‐19 patients with diabetes mellitus treated with convalescent plasma transfusion in Wuhan, China
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26712
Abstract: The coronavirus disease 2019 (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is wreaking havoc on public health systems worldwide. The diagnosis of COVID‐19 is well defined, but efficacious treatment is lacking.… read more here.
Keywords: covid patients; clinical outcomes; cpt; patients receiving ... See more keywords
Amphetamine improves rat 5-choice continuous performance test (5C-CPT) irrespective of concurrent low-dose haloperidol treatment
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05511-1
Abstract: Rationale Cognitive dysfunction mediates functional impairment in patients with schizophrenia, necessitating the timely development of pro-cognitive therapeutics. An important initial step in this process is to establish what, if any, pro-cognitive agents and associated mechanisms… read more here.
Keywords: amphetamine; cpt; choice continuous; continuous performance ... See more keywords
Expectations versus reality: trainee participation on the robotic console in academic surgery
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DOI: 10.1007/s00464-020-07874-0
Abstract: Introduction Trainees underestimate the amount of operative autonomy they receive, whereas faculty overestimate; this has not been studied in robotics. We aimed to assess the perceptions and expectations of our general surgery trainees and faculty… read more here.
Keywords: surgery; participation; trainee; cpt ... See more keywords
The Plant Alkaloid Camptothecin as a Novel Antifouling Compound for Marine Paints: Laboratory Bioassays and Field Trials
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DOI: 10.1007/s10126-018-9834-4
Abstract: The extensive use of copper and booster biocides in antifouling (AF) paints has raised environmental concerns and the need to develop new AF agents. In the present study, 18 alkaloids derived from terrestrial plants were… read more here.
Keywords: laboratory bioassays; camptothecin; cpt; field ... See more keywords
Modulation of Global and Local Processing Biases in Adults with Autistic-like Traits
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DOI: 10.1007/s10803-017-3198-x
Abstract: Previous work shows that doing a continuous performance task (CPT) shifts attentional biases in neurotypical individuals towards global aspects of hierarchical Navon figures by selectively activating right hemisphere regions associated with global processing. The present… read more here.
Keywords: local processing; processing; cpt; modulation global ... See more keywords
Final results of the Choroid Plexus Tumor study CPT-SIOP-2000
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-021-03942-0
Abstract: Standards for chemotherapy against choroid plexus tumors (CPT) have not yet been established. CPT-SIOP-2000 (NCT00500890) was an international registry for all CPT nesting a chemotherapy randomization for high-risk CPT with Carboplatin/Etoposide/Vincristine (CarbEV) versus Cyclophosphamide/Etoposide/Vincristine (CycEV).… read more here.
Keywords: cpc; siop 2000; choroid plexus; cpt siop ... See more keywords
CPT-Based Nonlinear Stress–Strain Approach for Evaluating Foundation Settlement: Analytical and Numerical Analysis
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DOI: 10.1007/s13369-019-04034-y
Abstract: Due to complexities in soil–foundation interaction and nonlinear behavior of subsoil, considerable uncertainty is involved in the foundation settlement evaluation. In the present paper, a new analytical approach is proposed to estimate the foundation settlement… read more here.
Keywords: cpt; foundation; approach; foundation settlement ... See more keywords
Synergistic antitumor efficacy of redox and pH dually responsive micelleplexes for co-delivery of camptothecin and genes.
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DOI: 10.1016/j.actbio.2016.12.005
Abstract: Challenges remain to load and deliver two or multiple drugs of complementary effects for synergistic cancer therapies. In the current study, multiarmed amphiphilic copolymers of 4-arm poly(ethylene glycol) (PEG) and polyaspartate (PAsp) are created for… read more here.
Keywords: tnf; cpt; delivery; treatment ... See more keywords
Irinotecan‐induced bile acid malabsorption is associated with down‐regulation of ileal Asbt (Slc10a2) in mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.03.012
Abstract: &NA; Irinotecan, (CPT‐11), an antitumor agent primarily used for the treatment of solid tumors, has often compromised clinical application due to the inducement of severe delay‐onset diarrhea. Bile acid malabsorption (BAM) is widely accepted as… read more here.
Keywords: cpt; treatment; asbt; acid malabsorption ... See more keywords