A Nitroreductase-Activated Chemiluminescent Prodrug for Real-Time Monitoring of Camptothecin Release in Peritoneal Metastasis Theranostics.
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DOI: 10.1021/acs.jmedchem.5c01674
Abstract: While most theranostic prodrugs utilize fluorescence for reporting, chemiluminescence offers superior signal-to-noise ratios. However, chemiluminescence-based prodrug systems remain relatively scarce. Herein, we report the development of CPT-NBz-CL, a novel hypoxia-responsive theranostic prodrug activated by nitroreductase… read more here.
Keywords: cpt nbz; chemiluminescence; peritoneal metastasis; camptothecin ... See more keywords