CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-024-02461-5
Abstract: Multiple theories have been proposed to explain the pathogenesis of early-onset preeclampsia (EOPE), and angiogenic dysfunction is an important part of this pathogenesis. Carnitine palmitoyltransferase (CPT1A) is a key rate-limiting enzyme in the metabolic process… read more here.
Keywords: cpt1a; expression; eope; mir 124 ... See more keywords
CPT1a downregulation protects against cholesterol-induced fibrosis in tubular epithelial cells by downregulating TGFβ-1 and inflammasome.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.121
Abstract: BACKGROUND Dyslipidemia causes renal damage; however, the detailed molecular mechanism has not been clarified. It is known that carnitine palmitoyl transferase 1-a (CPT1a) gene encodes an enzyme involved in fatty acid oxidation and, therefore, lipid… read more here.
Keywords: cpt1a downregulation; sma nlrp3; epithelial cells; cpt1a ... See more keywords
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.002
Abstract: T cell subsets including effector (Teff), regulatory (Treg), and memory (Tmem) cells are characterized by distinct metabolic profiles that influence their differentiation and function. Previous research suggests that engagement of long-chain fatty acid oxidation (LC-FAO)… read more here.
Keywords: fatty acid; cpt1a; independent cpt1a; cell ... See more keywords
Carnitine palmitoyltransferase 1A is essential for decidualization in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.10.006
Abstract: Decidualization accompanies with extensive stromal cell proliferation and differentiation, is a crucial step in early pregnancy. Aberrant decidualization is linked to infertility and miscarriage but the mechanisms remain unclear. Carnitine palmitoyltransferase 1A (CPT1A) is an… read more here.
Keywords: pregnancy; decidualization mice; carnitine palmitoyltransferase; cpt1a ... See more keywords
Overexpression of carnitine palmitoyltransferase 1A promotes mitochondrial fusion and differentiation of glioblastoma stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Laboratory Investigation"
DOI: 10.1038/s41374-021-00724-0
Abstract: Glioma stem cells (GSCs) are self-renewing tumor cells with multi-lineage differentiation potential and the capacity of construct glioblastoma (GBM) heterogenicity. Mitochondrial morphology is associated with the metabolic plasticity of GBM cells. Previous studies have revealed… read more here.
Keywords: differentiation; mitochondrial fusion; cpt1a; stem ... See more keywords
CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49868-6
Abstract: Human mutations in carnitine palmitoyl transferase 1A (CPT1A) are correlated with a remarkably low prevalence of multiple sclerosis (MS) in Inuits (P479L) and Hutterites (G710E). To elucidate the role of CPT1A, we established a Cpt1a… read more here.
Keywords: cpt1a p479l; p479l; disease; role ... See more keywords
CPT1A as a potential therapeutic target for lipopolysaccharide-induced acute lung injury in mice
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-52042-2
Abstract: Acute lung injury (ALI) remains a high mortality rate with dramatic lung inflammation and alveolar epithelial cell death. Although fatty acid β-oxidation (FAO) impairment has been implicated in the pathogenesis of ALI, whether Carnitine palmitoyltransferase… read more here.
Keywords: cpt1a; mice; ali; lung injury ... See more keywords
L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Acta physiologica"
DOI: 10.1111/apha.13975
Abstract: AIM To explore the beneficial effects of L-carnitine on cardiac microvascular dysfunction in diabetic cardiomyopathy from the perspectives of mitophagy and mitochondrial integrity. METHODS Male db/db and db/m mice were randomly assigned to groups and… read more here.
Keywords: cardiac microvascular; parl; cpt1a; mitophagy ... See more keywords
CPT1A Alleviates Senescence and Restores Osteogenic Differentiation of BM‐MSC Through SOD2 Succinylation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70473
Abstract: Bone marrow mesenchymal stem cells (BM‐MSCs) have promising prospects in bone repair and regenerative medicine. However, BM‐MSCs gradually lose their original pluripotency and differentiation potential after successive passages. This study aimed to reveal the mechanism… read more here.
Keywords: differentiation; senescence; sod2; cpt1a ... See more keywords
CPT1A mediated preservation of mitochondrial inhibits pyroptosis in pancreatic acinar cells
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1577669
Abstract: Introduction Carnitine palmitoyltransferase 1A (CPT1A) is crucial for mitochondrial function, and its dysfunction has been linked to the development of several diseases. However, the role of CPT1A in severe acute pancreatitis (SAP) and its underlying… read more here.
Keywords: acinar; pyroptosis; cpt1a; pancreatic acinar ... See more keywords
Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.549057
Abstract: Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of the present study was to investigate the… read more here.
Keywords: induced hepatotoxicity; activated protein; carnitine palmitoyltransferase; hepatotoxicity ... See more keywords