A novel CPT1C variant causes pure hereditary spastic paraplegia with benign clinical course
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.717
Abstract: Hereditary spastic paraplegia 73 (SPG73) was currently identified in only one family with variant in the neuronal isoform of carnitine palmitoyl‐transferase 1C (CPT1C) gene. We described a new family, in which affected individuals exhibited pure… read more here.
Keywords: pure hereditary; hereditary spastic; paraplegia benign; cpt1c ... See more keywords
CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023041
Abstract: Fatty acid oxidation (FAO) has been proven to be an accomplice in tumor progression. Carnitine palmitoyltransferase 1C (CPT1C), a rate-limiting enzyme in FAO, mainly functions to catalyze fatty acid carnitinylation and guarantee subsequent entry into… read more here.
Keywords: cell; cell proliferation; cpt1c; fatty acid ... See more keywords
Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.80822
Abstract: Cellular senescence is a state of proliferative arrest, and the development of carcinoma can be suppressed by conferring tumor cell senescence. Recently, we found that carnitine palmitoyltransferase 1C (CPT1C) controls tumor cell proliferation and senescence… read more here.
Keywords: senescence; stearate oleate; tumor cell; cpt1c ... See more keywords