Two component system CpxR/A regulates the prodigiosin biosynthesis by negative control in Serratia marcescens FS14.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.050
Abstract: Prodigiosin is a tripyrrole red secondary metabolite synthesized by many microorganisms, including Serratia marcescens. In this study, we found that the deletion of the gene of sensor kinase CpxA dramatically decreased the prodigiosin production, while… read more here.
Keywords: cpxr; prodigiosin biosynthesis; negative control; regulates prodigiosin ... See more keywords
The Yersinia pseudotuberculosis Cpx envelope stress system contributes to transcriptional activation of rovM
Sign Up to like & getrecommendations! Published in 2019 at "Virulence"
DOI: 10.1080/21505594.2018.1556151
Abstract: ABSTRACT The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one… read more here.
Keywords: rova expression; rovm; expression; cpxr ... See more keywords
Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response
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DOI: 10.1128/msystems.00419-22
Abstract: CpxRA system is found in many pathogens and plays an essential role in sensing environmental signals and transducing information inside cells for adaptation. It usually regulates expression of specific genes in response to different environmental… read more here.
Keywords: stress; cpxr; stress response; cpxra ... See more keywords
CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection
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DOI: 10.1128/spectrum.02430-21
Abstract: The increasing prevalence of urinary tract infections (UTIs) due to antibiotic-resistant uropathogenic Escherichia coli (UPEC) is a major public health concern. Bacteria contain proteins that sense their environment and have no human homologs and, thus,… read more here.
Keywords: phosphatase; uropathogenic escherichia; cpxr; escherichia coli ... See more keywords
Improved Prodigiosin Production by Relieving CpxR Temperature-Sensitive Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00344
Abstract: Prodigiosin (PG) is a typical secondary metabolite mainly produced by Serratia marcescens. CpxR protein is an OmpR family transcriptional regulator in Gram-negative bacteria. Firstly, it was found that insertion mutation of cpxR in S. marcescens… read more here.
Keywords: production; marcescens jnb; improved prodigiosin; cpxr ... See more keywords
Role of CpxR in Biofilm Development: Expression of Key Fimbrial, O-Antigen and Virulence Operons of Salmonella Enteritidis
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DOI: 10.3390/ijms20205146
Abstract: Salmonella Enteritidis is a non-typhoidal serovar of great public health significance worldwide. The RpoE sigma factor and CpxRA two-component system are the major regulators of the extracytoplasmic stress response. In this study, we found that… read more here.
Keywords: biofilm development; expression; biofilm; role ... See more keywords