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   Articles with "cpz" as a keyword



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Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T.

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recommendations! Published in 2023 at "NMR in biomedicine"

DOI: 10.1002/nbm.4937

Abstract: Chemical exchange saturation transfer (CEST) sensitively detects molecular alterations in the brain, such as relayed nuclear Overhauser effect (rNOE) CEST contrast at -3.5 ppm representing aliphatic protons in both lipids and proteins, and CEST contrast… read more here.

Keywords: cpz; cest; chemical exchange; pathology ... See more keywords
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Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination

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recommendations! Published in 2018 at "Journal of Molecular Histology"

DOI: 10.1007/s10735-018-9786-z

Abstract: Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration. Multiple… read more here.

Keywords: induced demyelination; demyelination; cuprizone; cpz ... See more keywords
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Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine

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recommendations! Published in 2020 at "International Journal of Antimicrobial Agents"

DOI: 10.1016/j.ijantimicag.2020.106274

Abstract: Introduction Urgent action is needed to fight the ongoing COVID-19 pandemic by reducing the number of infected people along with the infection contagiousness and severity. Chlorpromazine (CPZ), the prototype of typical antipsychotics from the phenothiazine… read more here.

Keywords: replication sars; drug; inhibition replication; cpz ... See more keywords
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Stereostructure-activity mechanism of cyproconazole by cytochrome P450 in rat liver microsomes: A combined experimental and computational study.

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recommendations! Published in 2021 at "Journal of hazardous materials"

DOI: 10.1016/j.jhazmat.2021.125764

Abstract: Cyproconazole (CPZ), representing the chiral triazole fungicides, is widely used in the pharmaceutical and agricultural fields. To clarify its potential adverse effects on the generalized CYP-mediated processes within mammalian, a comparative experimental and computational approach… read more here.

Keywords: metabolism; rat liver; experimental computational; cpz ... See more keywords
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Cuprizone‐induced demyelination in the mouse hippocampus is alleviated by phytoestrogen genistein

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recommendations! Published in 2019 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2018.11.009

Abstract: ABSTRACT One of the major female sex hormones, estrogen, can influence a variety of mental states. Individuals with multiple sclerosis (MS) often suffer from mental health issues, which are correlated with the pathology of gray… read more here.

Keywords: induced demyelination; phytoestrogen genistein; cpz; gen ... See more keywords
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Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering

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recommendations! Published in 2022 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2022.2110128

Abstract: Abstract Context Kuhuang (KH) injection is a widely used anticholestatic drug in the clinic and the mechanisms are still unclear. Objective This study uses a new 3D tissue-engineered (TE) liver platform to study the ability… read more here.

Keywords: cpz; ppar; liver injury; kuhuang ... See more keywords
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Chlorpromazine Impacts on the Length and Width of Sarcophaga haemorrhoidalis (Diptera: Sarcophagidae) Larvae: Potential Forensic Implications

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recommendations! Published in 2017 at "Journal of Entomological Science"

DOI: 10.18474/jes17-33.1

Abstract: Abstract The effect of chlorpromazine (CPZ) on the larval length and width of Sarcophaga haemorrhoidalis (Fallén) (Diptera: Sarcophagidae) was investigated under laboratory conditions for possible implications for forensic investigations. Fresh beef was treated with one… read more here.

Keywords: width sarcophaga; sarcophaga haemorrhoidalis; cpz; diptera sarcophagidae ... See more keywords
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Cuprizone-induced dopaminergic hyperactivity and locomotor deficit in zebrafish larvae

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recommendations! Published in 2022 at "Brain Research"

DOI: 10.2139/ssrn.3970449

Abstract: Cuprizone (CPZ) is a copper-chelator and toxic to mitochondria. Recent studies have shown oligodendrocyte (OL) loss and demyelination along with dopamine (DA) increase and behavioral abnormalities in CPZ-exposed mice, demonstrating its application in schizophrenia research.… read more here.

Keywords: cpz; hyperactivity locomotor; zebra fish; locomotor deficit ... See more keywords
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Dapsone reduced cuprizone-induced demyelination via targeting Nrf2 and IKB in C57BL/6 mice

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recommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"

DOI: 10.22038/ijbms.2022.64993.14310

Abstract: Objective(s): Multiple Sclerosis (MS) is an inflammatory disorder wherein the myelin of nerve cells in the central nervous system is damaged. In the current study, we assessed the effect of Dapsone (DAP) on the improvement… read more here.

Keywords: cpz; nrf2 ikb; demyelination; targeting nrf2 ... See more keywords
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Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.665832

Abstract: Medroxyprogesterone acetate (MPA) is the main conservative treatment for endometrial cancer (EC) patients desirable to preserve fertility and those who cannot suffer from surgery. Considering the high incidence of progestin resistance and recurrence of MPA… read more here.

Keywords: progestin; treatment; endometrial cancer; cpz ... See more keywords
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The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19

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recommendations! Published in 2020 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2020.577678

Abstract: Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome (SARS) in humans that is caused by SARS-associated coronavirus type 2 (SARS-CoV-2). In the context of COVID-19, several aspects of the relations between psychiatry and… read more here.

Keywords: large action; cpz; sars cov; chlorpromazine translational ... See more keywords