Associations of polymorphisms in the candidate genes for Alzheimer’s disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology Reports"
DOI: 10.1007/s11033-017-4100-9
Abstract: Alzheimer’s disease (AD) is the most common type of dementia, with a prevalence that is rising every year. AD is associated with type 2 diabetes mellitus (T2DM) and insulin resistance, and is therefore sometimes called… read more here.
Keywords: alzheimer disease; cr1; clu; candidate genes ... See more keywords
Hematopoietic Stem Cell Transplantation with Human Placenta-Derived Stem Cells Combined with Unrelated Cord Blood for Malignant and Non-Malignant Disorders (IND 14949)
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.293
Abstract: Background Myeloablative (MAC) or reduced toxicity conditioning (RTC) followed by UCBT in children with malignant and non-malignant diseases is safe and effective (Geyer/Cairo, BJH 2011). However, concentration of CD34+ HPCs in UCB is low, leading… read more here.
Keywords: blood; cell; malignant non; stem ... See more keywords
Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18937-z
Abstract: Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement… read more here.
Keywords: human complement; cr1; chagas disease; complement receptor ... See more keywords
Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes
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DOI: 10.1038/s41598-019-45228-6
Abstract: Plasmodium vivax parasites preferentially invade reticulocyte cells in a multistep process that is still poorly understood. In this study, we used ex vivo invasion assays and population genetic analyses to investigate the involvement of complement… read more here.
Keywords: invasion; surface; cr1; vivax invasion ... See more keywords
Durable outcomes of double cord blood transplantation in adults with acute lymphoblastic leukemia: high-risk features for early and long-term mortality
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Hematology"
DOI: 10.1177/20406207221076762
Abstract: Background: Cord blood transplantation (CBT) has been reported as an acceptable option with comparable outcomes to conventional donors in adults with acute lymphoblastic leukemia (ALL). We aimed to analyze the long-term CBT outcomes and risk… read more here.
Keywords: long term; cr1; cbt; incidence ... See more keywords
Risk Adapted Therapeutic Strategy of Acute Myeloid Leukemia
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DOI: 10.1182/blood-2019-125237
Abstract: In this "real-life" retrospective study, we assessed outcome after a "personalized" treatment strategy for patients with acute myeloid leukemia (AML) in a tertiary care center. Our strategy consisted of induction therapy adjusted to age, comorbidities… read more here.
Keywords: risk; allo sct; year; cr1 ... See more keywords
Population-specific positive selection on low CR1 expression in malaria-endemic regions
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DOI: 10.1371/journal.pone.0280282
Abstract: Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the… read more here.
Keywords: cr1; positive selection; cr1 expression; population ... See more keywords
Transposons-Based Clonal Diversity in Trematode Involves Parts of CR1 (LINE) in Eu- and Heterochromatin
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12081129
Abstract: Trematode parthenitae have long been believed to form clonal populations, but clonal diversity has been discovered in this asexual stage of the lifecycle. Clonal polymorphism in the model species Himasthla elongata has been previously described,… read more here.
Keywords: trematode; cr1 rng; line; cr1 ... See more keywords
Molecular Simulation Study on the Interaction between Porcine CR1-like and C3b
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DOI: 10.3390/molecules28052183
Abstract: The molecular basis of porcine red blood cell immune adhesion function stems from the complement receptor type 1-like (CR1-like) on its cell membrane. The ligand for CR1-like is C3b, which is produced by the cleavage… read more here.
Keywords: cr1 like; like c3b; interaction porcine; cr1 ... See more keywords
Crry silencing alleviates Alzheimer’s disease injury by regulating neuroinflammatory cytokines and the complement system
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.332160
Abstract: Complement component (3b/4b) receptor 1 (CR1) expression is positively related to the abundance of phosphorylated microtubule-associated protein tau (tau), and CR1 expression is associated with susceptibility to Alzheimer’s disease. However, the exact role of CR1… read more here.
Keywords: tau; cr1; complement; alzheimer disease ... See more keywords