CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons
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DOI: 10.1111/bph.14845
Abstract: CR4056 is a first‐in‐class imidazoline‐2 (I2) receptor ligand characterized by potent analgesic activity in different experimental animal models of pain. In a recent phase II clinical trial, CR4056 effectively reduced pain in patients with knee… read more here.
Keywords: cr4056 powerful; translocation; imidazoline receptor; receptor ligand ... See more keywords