A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47354-7
Abstract: The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras… read more here.
Keywords: raf; raf kinase; activation; retinoic acid ... See more keywords
Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.02302-18
Abstract: ATRA, a biologically active metabolite of vitamin A, exerts pleiotropic biological effects, including the activation of both innate and adaptive immunity, thereby serving as a potent antimicrobial compound against numerous viral pathogens. Despite the enrichment… read more here.
Keywords: replication; crabp1; life cycle; virus ... See more keywords
Cellular Retinoic Acid‐Binding Protein 1 Modulates Stem Cell Proliferation to Affect Learning and Memory in Male Mice
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2017-00353
Abstract: &NA; Retinoic acid (RA) is the active ingredient of vitamin A. It exerts its canonical activity by binding to nuclear RA receptors (RARs) to regulate gene expression. Increasingly, RA is also known to elicit nongenomic… read more here.
Keywords: learning memory; proliferation; stem cell; retinoic acid ... See more keywords
Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.689767
Abstract: Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related death and has a poor prognosis worldwide, thus, more effective drugs are urgently needed. In this article, a small molecule drug library composed of… read more here.
Keywords: hepatocellular carcinoma; hcc; cholesterol biosynthesis; maprotiline ... See more keywords
Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054980
Abstract: All-trans-retinoic Acid (atRA) is the principal active metabolite of Vitamin A, essential for various biological processes. The activities of atRA are mediated by nuclear RA receptors (RARs) to alter gene expression (canonical activities) or by… read more here.
Keywords: binding protein; acid binding; retinoic acid; acid ... See more keywords
Expression of cellular retinoic acid binding protein 1 predicts peritoneal recurrence of gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5353
Abstract: To improve the outcome of gastric cancer, novel markers that predict postoperative prognosis are required. For this purpose, the function of cellular retinoic acid binding protein 1 (CRABP1) in gastric cancer cells was investigated and… read more here.
Keywords: expression; retinoic acid; gastric cancer; crabp1 ... See more keywords