Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8704-7_13
Abstract: ORAI1 constitutes the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, a prototypical store-operated channel that is essential for the activation of cells of the immune system. Here we describe a convenient yet powerful… read more here.
Keywords: architecture crac; crac channel; pore architecture; cross linking ... See more keywords
STIM1 activation of Orai1.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.11.009
Abstract: A primary calcium (Ca2+) entry pathway into non-excitable cells is through the store-operated Ca2+ release activated Ca2+ (CRAC) channel. Ca2+ entry into cells is responsible for the initiation of diverse signalling cascades that affect essential… read more here.
Keywords: activation orai1; crac channel; stim1 activation; activation ... See more keywords
A novel STIM1-Orai1 gating interface essential for CRAC channel activation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.02.009
Abstract: Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+ release-activated Ca2+ (CRAC) channel. STIM1, a key molecular component… read more here.
Keywords: orai1 gating; stim1; crac channel; stim1 orai1 ... See more keywords
Sequential Steps of CRAC Channel Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.025
Abstract: Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood. Using electrophysiological, optical,… read more here.
Keywords: orai1; steps crac; crac channel; sequential steps ... See more keywords
The Role of Lipids in CRAC Channel Function
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030352
Abstract: The composition and dynamics of the lipid membrane define the physical properties of the bilayer and consequently affect the function of the incorporated membrane transporters, which also applies for the prominent Ca2+ release-activated Ca2+ ion… read more here.
Keywords: function; crac channel; role lipids; membrane ... See more keywords
Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.84708
Abstract: The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions… read more here.
Keywords: crac channel; crac; channel function; metabolic reprogramming ... See more keywords