A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations
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DOI: 10.1073/pnas.2000361117
Abstract: Significance A strategy to overcome therapeutic obstacles of mKRAS and mBRAF cancers is devised based on the finding, here, that the RAF/MEK/ERK cascade is by-passed by an autocrine signal loop established by interaction of CRAF… read more here.
Keywords: craf; mkras mbraf; gstp1; craf glutathione ... See more keywords