Chiral Phosphoric Acid Catalyzed Desymmetrization of Cyclopentendiones via Friedel-Crafts Conjugate Addition of Indolizines.
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DOI: 10.1021/acs.orglett.1c03780
Abstract: An organocatalytic highly diastero- and enantioselective Friedel-Crafts conjugate addition of indolizines to prochiral cyclopentenediones has been successfully developed. This desymmetric transformation provides a direct access to the desired indolizine-substituted cyclopentanediones in yields of 62-91% and… read more here.
Keywords: addition indolizines; crafts conjugate; friedel crafts; conjugate addition ... See more keywords