Defensins defend against bone loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1597-2
Abstract: Defensins are small, cysteine-rich cationic proteins contained within cells of the immune system. The defensin peptides assist in killing phagocytosed bacteria in neutrophils and in many epithelial cell types. Most defensins function by binding to… read more here.
Keywords: defensins defend; defensin; cramp; bone ... See more keywords
Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105021
Abstract: Cathelicidin antimicrobial peptides (human LL-37 and mouse CRAMP) are mainly virucidal to enveloped virus. However, the effects and relative mechanism of LL-37 and CRAMP on non-enveloped virus are elusive. We herein found that CRAMP expression… read more here.
Keywords: response; cramp; infection; cathelicidin antimicrobial ... See more keywords
Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2021.104689
Abstract: The aim of this study was to analyze the expression of mBD4, mBD3 and CRAMP in joint of mice with type II collagen-induced arthritis/CIA and to explore its possible association with IL-10, IL-4, IFN-γ, IL-17,… read more here.
Keywords: peak phase; phase; cramp; ifn ... See more keywords
Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.35736
Abstract: Cathelicidin-related antimicrobial peptide (CRAMP), antimicrobial peptide, was reported to protect against myocardial ischemia/reperfusion injury. In the pathology of diabetic cardiomyopathy, endothelial-to-mesenchymal transition (EndMT) results from hyperglycemia-induced endothelial injury, leading to cardiac fibrosis. This study aims… read more here.
Keywords: mice heart; fibrosis; cramp; cardiac fibrosis ... See more keywords
Cathelicidin-related antimicrobial peptide protects against enteric pathogen-accelerated type 1 diabetes in mice
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.61433
Abstract: Rationale: Gut barrier disruption caused by enteric pathogen infection results in activated diabetogenic T cells and accelerated type 1 diabetes (T1D). Cathelicidin-related antimicrobial peptide (CRAMP) maintains intestinal barrier integrity, regulates the microbiome, and exerts positive… read more here.
Keywords: gut; cramp; rodentium; gut barrier ... See more keywords