Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors
Sign Up to like & getrecommendations! Published in 2020 at "Osteoporosis International"
DOI: 10.1007/s00198-020-05285-4
Abstract: Summary We investigated if bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. Men with untreated testosterone deficiency or previous treatment with cranial irradiation were… read more here.
Keywords: ccs; bmd; cranial irradiation; cancer ... See more keywords
Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2021.06.009
Abstract: Highlights • Prophylactic cranial irradiation (PCI) was more commonly used in younger patients.• PCI utilization rates did not change throughout our 20-year institutional experience.• PCI was associated with improved OS and lower brain metastasis risk,… read more here.
Keywords: limited stage; year; prophylactic cranial; cranial irradiation ... See more keywords
Prophylactic Cranial Irradiation or No Prophylactic Cranial Irradiation after Adjuvant Chemotherapy in Resected Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2016.12.002
Abstract: http://dx.doi.org/10.1016/j.jtho.2016.12.002 In the literature, there are limited data on thoracic surgery in patients with SCLC and even more scarce data on prophylactic cranial irradiation (PCI) in these same patients. The main reason is that because… read more here.
Keywords: stage; prophylactic cranial; cranial irradiation; adjuvant chemotherapy ... See more keywords
Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extracranial Irradiation for Extensive‐Disease Small Cell Lung Cancer (ED SCLC): NRG Oncology RTOG 0937
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2017.06.015
Abstract: Introduction: NRG Oncology RTOG 0937 is a randomized phase II trial evaluating 1‐year overall survival (OS) with prophylactic cranial irradiation (PCI) or PCI plus consolidative radiation therapy (PCI+cRT) to intrathoracic disease and extracranial metastases for… read more here.
Keywords: pci crt; prophylactic cranial; oncology; cranial irradiation ... See more keywords
Cranial irradiation at early postnatal age impairs stroke-induced neural stem/progenitor cell response in the adult brain
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69266-7
Abstract: Cranial irradiation (IR) is commonly used to treat primary brain tumors and metastatic diseases. However, cranial IR-treated patients often develop vascular abnormalities later in life that increase their risk for cerebral ischemia. Studies in rodents… read more here.
Keywords: response; postnatal age; early postnatal; cranial irradiation ... See more keywords
Secondary meningioma after cranial irradiation: case series and comprehensive literature review.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac191
Abstract: BACKGROUND Secondary meningioma after cranial irradiation, so-called radiation-induced meningioma, is one of the important late effects after cranial radiation therapy. In this report, we analyzed our case series of secondary meningioma after cranial irradiation and… read more here.
Keywords: cranial irradiation; meningioma cranial; latency; secondary meningioma ... See more keywords
Role of prophylactic cranial irradiation for elderly patients with limited-disease small-cell lung cancer: inverse probability of treatment weighting using propensity score
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz040
Abstract: Abstract Studies of prophylactic cranial irradiation (PCI) focused on elderly patients with small-cell lung cancer (SCLC) are rarely conducted. We aimed to identify whether there is a survival benefit of prophylactic cranial irradiation (PCI) in… read more here.
Keywords: prophylactic cranial; disease; elderly patients; cranial irradiation ... See more keywords
Cranial irradiation alters neuroinflammation and neural proliferation in the pituitary gland and induces late‐onset hormone deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16086
Abstract: Cranial radiotherapy induces endocrine disorders and reproductive abnormalities, particularly in long‐term female cancer survivors, and this might in part be caused by injury to the pituitary gland, but the underlying mechanisms are unknown. The aim… read more here.
Keywords: hormone; irradiation; proliferation; pituitary gland ... See more keywords
Cranial Irradiation for Childhood Cancers and Adult Risk of Meningioma
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Neurosurgery"
DOI: 10.1159/000527565
Abstract: Introduction: Following cranial irradiation, there is an increased risk of developing secondary neoplasms, especially meningiomas. Despite childhood cancer survivors who have undergone cranial irradiation having an increased risk of acquiring radiation-induced meningioma (RIM), there is… read more here.
Keywords: diagnosis; cranial irradiation; childhood; age ... See more keywords
Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5251-3
Abstract: BackgroundThe efficacy of prophylactic cranial irradiation (PCI) in treating patients with small cell lung cancer (SCLC) has not been clear, and recent randomized studies have demonstrated conflicting results from previously published findings. The purpose of… read more here.
Keywords: analysis; prophylactic cranial; cranial irradiation; cancer ... See more keywords
Effects of cranial irradiation on dendritic spine complexity in the rat hippocampus and to induce memory decline.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e13545
Abstract: e13545Background: Cognitive deficit was the most serious complication of cranial irradiation in brain metastatic carcinoma. However, the underlying mechanisms remain obscure. Dendrites are the anatomic bases of synaptic contact and action potential propagation. Alterations of… read more here.
Keywords: dendritic spine; memory; effects cranial; cranial irradiation ... See more keywords